HomeNFLNFL PredictionsBuffalo Bills vs Cleveland Browns Prediction, Odds and Picks

Buffalo Bills vs Cleveland Browns Prediction, Odds and Picks for Sunday, 12/21/25

Updated: 12:25 AM ET Dec 19, 2025

Huntington Bank FieldCBS

Bills

1:00 PM ETSun Dec 21

Browns

WLWWW	Last 5	LWLLL
10-4	Record	3-11
7-7-0	ATS Record	5-9-0
7-7	O/U Record	7-7

Bills vs Browns Best Bets

Point Spread PickBest Bet

BUF Bills -10(-125)

Reasoning

The Buffalo Bills will try to build on a massive win over their AFC East rival Patriots when they visit the Cleveland Browns in Week 16 of the NFL season on Sunday afternoon. My Bills vs. Browns pick is for the visitors to win and cover. If there is one thing we learned from Week 15, it’s that big spreads are often not big enough. There are simply some awful football teams this year; one such team is the Browns. They are 3-11 and have lost 3 games in a row, including by 18 points to San Francisco and by a 31-3 margin at Chicago this past Sunday. Cleveland even lost to lowly Tennessee during this stretch. Rookie QB Shedeur Sanders has been better than Dillon Gabriel — but that’s not saying much. Head coach Kevin Stefanski’s squad is 3rd-to-last in total offense, and only Las Vegas is averaging fewer points per game than Cleveland.

There are also a lot of really good teams this year, including the Bills. They may not be where they want since the Patriots still lead the AFC East, but Josh Allen and company are 10-4 and coming off a huge road win at New England to keep their division-title hopes alive. At the very least, the Bills are well on their way to another playoff berth. These are simply 2 squads going in very different directions. As such, this is one of those double-digit spreads that still isn’t big enough. The Browns are 0-3 ATS in their last 3 overall and 2-5 ATS in the last 7 head-to-head meetings.

Bills vs Browns predictions: Buffalo Bills -10 (-125) available at time of publishing. Playable to -12.5.

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Bills vs Browns Pickswise Expert Predictions

Game Totals Pick

Over 41.5(-108)

Reasoning

The Browns really have just one bright spot in 2025, which is obviously defensive end Myles Garrett. Of course, Allen is one of the best quarterbacks in the NFL and is extremely mobile — he is not easy to bring down in the backfield. Even against a respectable Cleveland defense, I think Allen and the entire Buffalo offense are in line for a productive outing. As such, my Bills vs. Browns pick is Over 41.5.

The Bills just torched a stout Patriots defense for 35 points, with all 35 coming in the final 3 quarters — including 28 in the second half — after New England once led 21-0. To say that Buffalo’s offense has a ton of momentum right now would be a gross understatement. On the other side of the ball, Sanders is at least showing some signs of promise for the Browns. They have scored at least 24 points in 2 of Sanders’ 4 NFL starts. In general, Cleveland is a run-first team, which is good news since Buffalo is the third-worst rushing defense in the league. It’s a lean toward the over for me.

Bills vs Browns prediction: Over 41.5 (-108) available at time of publishing. Playable to 42.

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Show Bio

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.

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