Buffalo Bills vs Tampa Bay Buccaneers Prediction, Odds and Picks for Saturday, 08/23/25
Bills vs Buccaneers Pickswise Expert Predictions
The Bills rested their starters last week against the Bears and got blown out by a score of 38-0. It’s still just the preseason, but Sean McDermott will want a better effort from his group in this one. The Bills open the regular season on Sept. 7 in a prime time matchup against the Ravens. As that heavyweight battle draws nearer, the Bills will want to tune things up in this preseason finale against the Buccaneers.
Tampa Bay has won each of its first 2 preseason contests. The Bucs have few starting roles left to figure out, especially on the offensive side. Head coach Todd Bowles has to be pleased with what he’s seen from his team so far this preseason, so he could just want to get through this contest without any major developments. Back the Bills in this one.
Bills vs Buccaneers prediction: Bills -3 (+100) available at time of publishing. Playable to -110.
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Connor Grootenhuis
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