Carolina Panthers vs New Orleans Saints Prediction, Odds and Picks for Sunday, 12/14/25

It will be a showdown in the NFC South when the Carolina Panthers visit the New Orleans Saints on Sunday afternoon. New Orleans did Carolina a solid by upsetting division-rival Tampa Bay in Week 14, but the Panthers won’t return the favor by playing nice this weekend. After all, they are now in the thick of a division race. The door is open for the Panthers and — at least for the time being — I expect them to walk through it. My Panthers vs Saints pick is for the visitors to win and cover. This is a fantastic spot for the visitors. Carolina is coming off a bye and facing an opponent that just picked up its biggest win of the season, thus inflating its value.

The Saints are very bad — way worse than this 2.5-point spread indicates. Their season-long sample size confirms that this is a far inferior team compared to what was on display at Tampa Bay this past weekend. The Bucs really aren’t that good, either. In fact, they have been in shambles since a hot start to the 2025 campaign — their record since a Week 9 bye is 1-4. The Saints gained only 260 yards of total offense but still managed to prevail 24-20. Now they return to the Big Easy, but their is no home-field advantage for them these days. They are 1-5 at the Mercedes-Benz Dome this season compared to 2-5 on the road. Meanwhile, the Panthers are 6-3 SU in their last 9 overall and find themselves tied atop the NFC South with the Bucs. Carolina most recently stunned the Rams in Week 13 as Bryce Young continued to heat up. Young has thrown at least 3 touchdown passes in 4 games so far in 2025.

Carolina Panthers vs New Orleans Saints prediction: Panthers -2.5 (-115) available at time of publishing. Playable to -3.

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