HomeNFLNFL PredictionsCarolina Panthers vs New Orleans Saints Predictions, Odds & Expert Picks for NFL Week 15 2025

Carolina Panthers vs New Orleans Saints Predictions, Odds & Expert Picks for NFL Week 15 2025 for Today, 12/14/25

Updated: 4:52 AM ET Dec 14, 2025

Caesars SuperdomeFOX

Panthers

4:25 PM ETToday

Saints

WLWLW	Last 5	LWLLW
7-6	Record	3-10
8-5-0	ATS Record	5-8-0
7-6	O/U Record	4-9

Panthers vs Saints Best Bets

Point Spread PickBest Bet

CAR Panthers -2.5(-115)

Reasoning

It will be a showdown in the NFC South when the Carolina Panthers visit the New Orleans Saints on Sunday afternoon. New Orleans did Carolina a solid by upsetting division-rival Tampa Bay in Week 14, but the Panthers won’t return the favor by playing nice this weekend. After all, they are now in the thick of a division race. The door is open for the Panthers and — at least for the time being — I expect them to walk through it. My Panthers vs. Saints pick is for the visitors to win and cover. This is a fantastic spot for the visitors. Carolina is coming off a bye and facing an opponent that just picked up its biggest win of the season, thus inflating its value.

The Saints are very bad — way worse than this 2.5-point spread indicates. Their season-long sample size confirms that this is a far inferior team compared to what was on display at Tampa Bay this past weekend. The Bucs really aren’t that good, either. In fact, they have been in shambles since a hot start to the 2025 campaign — their record since a Week 9 bye is 1-4. The Saints gained only 260 yards of total offense but still managed to prevail 24-20. Now they return to the Big Easy, but there is no home-field advantage for them these days. They are 1-5 at the Caesars Superdome this season, compared to 2-5 on the road. Meanwhile, the Panthers are 6-3 SU in their last 9 overall and find themselves tied atop the NFC South with the Bucs. Carolina most recently stunned the Rams in Week 13 as Bryce Young continued to heat up. Young has thrown at least 3 touchdown passes in 4 games so far in 2025.

Panthers vs Saints prediction: Carolina Panthers -2.5 (-115) available at time of publishing. Playable to -3.

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Panthers vs Saints Pickswise Expert Predictions

Game Totals Pick

Under 40.5(-110)

Reasoning

Only 24 total points were scored in the first head-to-head matchup of this 2025 campaign. Now we’re asking Carolina and New Orleans to combine for at least 41?!?! It’s a no from me. My Panthers vs. Saints pick is Under 40.5. The Saints have played 13 games this season; only 3 times have they reached the 20-point mark — and in those 3 exceptions their outputs were 21, 24 and 26 points. Despite prevailing at Tampa Bay 24-40 this past weekend, New Orleans’ offense amassed a grand total of 260 yards. Running back Alvin Kamara is a shadow of his former self and is questionable for Sunday due to a knee injury.

Somewhat surprisingly, neither defense is terrible. Carolina’s is arguably above average, while New Orleans is at least quite good against the pass — #6 in the NFL in that department. The Panthers are tied for 10th in the league with 17 takeaways and the Saints have committed the 3rd-most turnovers with 20. It’s just hard to see this matchup developing into a high-scoring or even medium-scoring affair. Something along the lines of their first head-to-head encounter is far more likely.

Panthers vs Saints prediction: Under 40.5 (-110) available at time of publishing. Playable to 39.5.

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Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.

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