Cincinnati Bengals

Cincinnati Bengals vs Buffalo Bills Predictions, Odds & Expert Picks for NFL Week 14 2025 for Today, 12/07/25

Highmark StadiumCBS
Bengals
Bengals
Today
Bills
Bills
LLLLW
Last 5
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4-8Record8-4
5-7-0ATS Record6-6-0
7-5O/U Record5-7
Buffalo Bills

Bengals vs Bills Pickswise Expert Predictions

Point Spread Pick
BUF Bills -5.5(-110)

The Bengals made waves on Thanksgiving night by pulling off an upset as underdogs of nearly a touchdown against the Ravens in Baltimore. On first glance, Joe Burrow’s return seemed to spark the Cincinnati offense and it seemed to be a more inspired effort from the Bengals defense en route to a win that somehow kept them alive in what is suddenly a very weak AFC North division race. However, I’m of the opinion that the narrative on Burrow and the Bengals has gotten a little out of hand heading into this week’s contest, which gives us a bit of value on Buffalo this week.

For starters, much of the talk has been about Cincinnati’s newfound offense, but the Bengals registered one of the bottom 5 success rates of any team that played a week ago, and that was against a pretty banged-up Ravens defense in the back end. Joe Burrow and this offense only averaged 4.8 yards per play and was consistently set up with good field position. It’s hard to assume that this will happen again this week, especially considering Buffalo’s defensive front is playing better following a couple of solid showings against Houston and Pittsburgh. Even though Cincinnati’s offense is a step-up in class compared to those units, it’s hard not to see Buffalo generating pressure when matched up against this Bengals offensive line.

On the other side of the ball, while Cincinnati’s defense is certainly playing better than in weeks past, it still benefited from five Baltimore turnovers a week ago, including a fumble out of the end zone as the Ravens were going in for a touchdown that completely changed the momentum of the game. Considering the fact that Josh Allen and the Bills are due for a bit of turnover regression at home following a string of fumbles and tipped interceptions over the last 4 weeks, we can expect Buffalo to play a cleaner and more efficient game in a spot where it has historically been successful in recent years. I’ll lay the points with a Bills offense that is getting healthier while fading the Cincinnati hype train.

Bengals vs Bills prediction: Bills -5.5 (-110) available at time of publishing. Playable to -6. 

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Game Totals Pick
Under 53.5(-110)

Even though a quarterback matchup like this one will push many in the direction of the over, I can’t get there given how the Bills want to operate. We know that Buffalo wants to run the ball, as Joe Brady’s offense has the highest rush rate of any team in football. Furthermore, the Bills should want to keep their defense off the field as much as possible against Burrow and the Cincinnati offense, which should lead to longer drives with plenty of sequences where Buffalo takes 30+ seconds between plays. On the other side, I discussed how Cincinnati’s offense has been retroactively overrated a bit following last week’s game, and it’s still undetermined if Tee Higgins is going to suit up in what should be very cold and somewhat windy conditions on Sunday. I’ll take the under at the current number.

Bengals vs Bills prediction: Under 53.5 (-110) available at time of publishing. Playable to 53.

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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.
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Top Trends
Point Spread

The Bills have covered in both of their matchups against AFC North teams this season.

Money Line

The Bills have won 4 of their last 5 matchups against AFC North teams.

Game Totals

The Under has cashed in the Bengals' last 3 games.

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