Green Bay Packers vs Chicago Bears Prediction, Odds and Picks for Saturday, 12/20/25

One of the most consequential games on the NFL Week 16 slate comes in Chicago, where the Bears are going to take on the Green Bay Packers in a massive showdown in the NFC North. These teams just met two weeks ago in Green Bay, and the Packers were able to come out on top in a game that came down to the final possession. This time around, Chicago is in a much better position as a team, and I actually make the Bears a small favorite in this game given the key injuries that Green Bay has sustained in recent weeks. Ben Johnson’s group was just in a very difficult situational spot against the Browns a week ago, and this offense didn’t miss a beat against the stout Cleveland defense, as Chicago racked up 31 points and dominated the game from start to finish at home. Caleb Williams is playing the best football of his young NFL career at the moment, while the Bears defense has shown signs of improvement of late. Given the fact that Chicago came up just a few yards short of sending the previous meeting between these teams to overtime, it’s hard not to favor Williams and company to pick up a possible division-clinching win at home.

While Chicago has impressed me in recent weeks, the Packers are a team that I’ll be looking to fade in the immediate future, albeit through no fault of their own. Green Bay is still one of the best teams in the NFC, but the Packers’ hopes of winning a Super Bowl were essentially dashed a week ago when Micah Parsons went down with a torn ACL in a loss to the Broncos. The rest of the Green Bay defense is still very solid, but it’s hard to quantify just how much of a difference-maker Parsons is in a variety of areas. Elsewhere, the Packers might also be without top wide receiver Christian Watson in this game, and that doesn’t bode well for Jordan Love’s downfield passing efficiency against an opportunistic Bears secondary that has made a living on forcing turnovers this season. I’ll back the home ‘dog while I’m still getting plus-money in what should be a terrific game on Saturday.

Packers vs Bears prediction: Bears ML (+100) available at time of publishing. Playable to -110.

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