Green Bay Packers vs Detroit Lions Prediction, Odds and Picks for Thursday, 11/27/25

Thanksgiving Day features a trio of excellent NFL games, and one of the most consequential matchups of the weekend comes in the NFC North, where the Detroit Lions are set to host the Green Bay Packers in a rematch of a Week 1 contest in which Green Bay dominated the proceedings. Both of these teams have been up-and-down all season long, with the Lions struggling to generate consistent success against strong defenses without the services of Ben Johnson as offensive coordinator, while the Packers are also searching for more consistency on a week-to-week basis on offense. Even in last week’s convincing win over Minnesota, Jordan Love and company were still held to less than 300 total yards of offense and largely benefitted from being plus-three in turnovers. However, what Green Bay does have is a very strong defense, which has the ability to generate pressure on Jared Goff and force the veteran quarterback into mistakes, much like we saw in the Week 1 meeting between these teams. As long as the Packers can somewhat limit the effectiveness of Jahmyr Gibbs on the ground, they should do a solid job of getting this Detroit offense off the field.

As for the hosts, the Lions have typically been an excellent team at home in the Dam Campbell era, but it has been tough sledding for Detroit in its recent home games. In fact, the Lions have been struggling against inferior competition, with Detroit losing outright as a significant favorite to the Vikings and needing overtime to get past the lowly Giants last week. This is not the same offense that we are used to seeing out of the Lions, and Johnson’s absence has clearly been felt in the first season with a new play-caller at the controls. On the other side of the ball, Detroit’s defense has allowed a combined 54 points in its last 2 home games against the likes of J.J. McCarthy and Jameis Winston. That doesn’t bode well for the Lions in this NFC North showdown.

Packers vs Lions prediction: Packers ML (+125) available at time of publishing. Playable to +115.

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