Houston Texans vs Indianapolis Colts Prediction, Odds and Picks for Sunday, 11/30/25

Once 0-3, the surging Houston Texans are breathing down the necks of the Indianapolis Colts in the AFC South. That makes Sunday’s Week 13 showdown in Indianapolis an absolutely crucial contest. There is simply no way I’m giving more than a field goal in this kind of division-rivalry game, especially when Houston is on such a roll — 6-2 in its last 8 outings. As such, my Texans vs Colts prediction is for the visitors to cover. Head coach DeMeco Ryans’ defense is coming off a dominant defensive performance on Thursday Night Football in Week 3, paving the way to a 23-19 upset of the Bills. Houston forced 3 turnovers (2 Josh Allen interceptions), limited Buffalo to 4.9 yards per play and sacked Allen a ridiculous 8 times for a total of 70 lost yards. 
 
Since the Texans played on Thursday, they are effectively on a mini-bye week. They are well rested and armed with a ton of momentum, whereas the Colts just suffered a tough loss at Kansas City. Prior to that result, Indianapolis needed overtime to get past a mediocre-at-best Atlanta squad in Berlin. Quarterback Daniel Jones was playing awesome football earlier this season, but he has come back down to Earth over the past 3 games. Jones going up against this ferocious Texans defense — and specifically a pass rush spearheaded by Will Anderson Jr. and Danielle Hunter — spells serious trouble for the home team.

Houston Texans vs Indianapolis Colts prediction: Houston +4.5 (-110) available at time of publishing. Playable to +3.

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