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Houston Texans

Houston Texans vs Indianapolis Colts Predictions, Odds & Expert Picks for NFL Week 13 2025 for Today, 11/30/25

Lucas Oil StadiumCBS
Texans
Texans
Today
Colts
Colts
WLWWW
Last 5
WWLWL
6-5Record8-3
5-6-0ATS Record7-3-1
3-8O/U Record6-5
Indianapolis Colts

Texans vs Colts Best Bets

Point Spread PickBest Bet
HOU Texans +4.5(-110)

Once 0-3, the surging Houston Texans are breathing down the necks of the Indianapolis Colts in the AFC South. That makes Sunday’s Week 13 showdown in Indianapolis an absolutely crucial contest. There is simply no way I’m giving more than a field goal in this kind of division-rivalry game, especially when Houston is on such a roll — 6-2 in its last 8 outings. As such, my Texans vs Colts prediction is for the visitors to cover. Head coach DeMeco Ryans’ defense is coming off a dominant defensive performance on Thursday Night Football in Week 3, paving the way to a 23-19 upset of the Bills. Houston forced 3 turnovers (2 Josh Allen interceptions), limited Buffalo to 4.9 yards per play and sacked Allen a ridiculous 8 times for a total of 70 lost yards. 
 
Since the Texans played on Thursday, they are effectively on a mini-bye week. They are well rested and armed with a ton of momentum, whereas the Colts just suffered a tough loss at Kansas City. Prior to that result, Indianapolis needed overtime to get past a mediocre-at-best Atlanta squad in Berlin. Quarterback Daniel Jones was playing awesome football earlier this season, but he has come back down to Earth over the past 3 games. Jones going up against this ferocious Texans defense — and specifically a pass rush spearheaded by Will Anderson Jr. and Danielle Hunter — spells serious trouble for the home team.

Texans vs Colts prediction: Houston Texans +4.5 (-110) available at time of publishing. Playable to +3.

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Ricky Dimon

Texans vs Colts Pickswise Expert Predictions

Game Totals Pick
Under 44.5(-108)

Everything about this Houston team provides a recipe for low-scoring affairs, so my Texans vs Colts pick is under 44.5. Unfortunately for the visitors, their incredible defense is not exactly complemented by an overly productive offense. Running back Joe Mixon has been out for the entire season, and the injury-plagued Nick Chubb is a shadow of his former self, so there is little ground game of which to speak. Woody Marks has done his best to fill in, but he is not a serious threat. The Texans, in all likelihood, will also once again be playing with their backup quarterback, Davis Mills. CJ Stroud remains in the NFL’s concussion protocol and is questionable for this weekend. Mills can play mistake-free football, but he isn’t a real threat.

Indianapolis RB Jonathan Taylor is obviously dangerous, but Houston’s defense is also stout against the run. It ranks #5 league wide in rushing defense, giving up just 92.2 yards per contest. Taylor is coming off his worst outing of the season, having been limited to 66 yards from scrimmage (58 on the ground) by Kansas City. As for Jones, he has almost as many interceptions (4) as touchdown passes (5) over the past 3 games. The number is low, so I would proceed with caution — but the under is the play for these 2 teams.

Texans vs Colts prediction: Under 44.5 (-110) available at time of publishing. Playable at that number.

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Ricky Dimon
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Ricky Dimon

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.
@Dimonator133
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Money Line

The Colts have won 4 straight divisional matchups.

Point Spread

The Colts have covered in 7 of their 11 games this season.

Game Totals

6 of the Colts' last 8 matchups against AFC South teams have gone over the Total.

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