Houston Texans vs Tennessee Titans Prediction, Odds and Picks for Today, 11/16/25

An AFC South battle here as the Tennessee Titans host the Houston Texans. The Titans fired Brian Callahan a few weeks ago to try to give the team a spark, but so far that hasn’t materialized. They’ve lost each of their 3 games since switching to interim coach Mike McCoy, by an ugly combined score of 96-47. The defense has been consistently terrible, while Cam Ward continues to play alarmingly poorly for a number one overall pick, no matter how bad his circumstances are.

On the flip side, the Texans started slow but are coming on strong, even managing to win a shootout with Jacksonville last week despite CJ Stroud being out with a concussion. Stroud is going to miss this one too, but there’s no need to overreact like oddsmakers have. Davis Mills is a competent NFL quarterback, and he showed that while throwing for 292 yards and two touchdowns last week in the comeback win against the Jags.

Houston has gone 4-2 in their last 6, with the only two losses in that span coming in one possession games to very good Seahawks and Broncos teams. 3 of their 4 wins in that span have come by 11+, and all of them have been by at least a touchdown, so they’ve been playing some genuinely good ball lately. The same can’t be said for Ward, who is completing less than 60 percent of his passes, averaging just 6.0 yards per attempt, with more interceptions than touchdowns. In addition to that he’s also taking a truly ridiculous amount of sacks, absorbing 38 across 9 games.

Texans -6 at publishing.