Indianapolis Colts vs Cincinnati Bengals Prediction, Odds and Picks for Saturday, 08/23/25

The Bengals have gotten out of the gate slow in recent years. As Cincinnati looks to start fast in 2025, look for head coach Zac Taylor to emphasize a hot beginning on offense in the preseason finale. Whether or not that involves Joe Burrow at all remains to be seen, but even if he doesn’t play, Jake Browning and Desmond Ridder have a decent amount of NFL experience to hold their own.

Cincinnati’s defense remains a concern, and some last-minute tinkering in the preseason finale isn’t going to correct the bigger flaws that remain. The Colts and Bengals have played some high-scoring games so far this preseason. With a combined average total score of over 45 points per game, the Over is a combined 4-0 for Indianapolis and Cincinnati. Look for that trend to continue in this one.

Colts vs Bengals prediction: Over 35 (-110) available at time of publishing. Playable to -115.

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