HomeNFLNFL PredictionsIndianapolis Colts vs Jacksonville Jaguars Predictions, Odds & Expert Picks for NFL Week 14 2025

Indianapolis Colts vs Jacksonville Jaguars Predictions, Odds & Expert Picks for NFL Week 14 2025 for Sunday, 12/07/25

Updated: 8:20 AM ET Dec 04, 2025

EverBank StadiumCBS

Colts

1:00 PM ETSun Dec 7

Jaguars

WLWLL	Last 5	WLWWW
8-4	Record	8-4
7-4-1	ATS Record	7-5-0
6-6	O/U Record	6-6

Colts vs Jaguars Pickswise Expert Predictions

Point Spread Pick

IND Colts -1.5(-110)

Reasoning

The AFC South race looked like a runaway in early November when the Indianapolis Colts (8-4) owned a 7-1 mark. The Jacksonville Jaguars (8-4) sat at 4-3 at the time and were hoping to sneak into the playoffs as a Wild Card team. One month later, the Colts and Jaguars are playing with first place on the line and the Houston Texans are hanging around, sitting 1 game back, which makes this anyone’s division to win heading into December.

The Colts lost their second straight game by less than 4 points in last Sunday’s 20-16 home defeat to the Texans as 3-point favorites. Indianapolis QB Daniel Jones is dealing with a fractured fibula and completed 14-of-27 passes, which was by far his worst completion rate of the season at 51.9%. In 6 of the last 8 games, Jones has thrown at least 2 touchdown passes, including in the loss to Houston. Following that loss, the Colts fell to 1-3-1 against the spread in the last 5 opportunities in the favorite role.

The Jaguars have won 4 of their last 5 games with the lone loss coming in that Week 10 meltdown at Houston, 36-29. Jacksonville has rebounded with 3 consecutive victories, capped off by a pair of road victories at Arizona and Tennessee. Sunday marks only the second home game for Jacksonville since Week 6 when the Jaguars lost to the Seahawks, 20-12. The home schedule sets up nicely for the Jags, who host the Jets next Sunday and close things out in Week 18 against the Titans.

Both teams are 7-4-1 ATS, as Jacksonville is 4-1 ATS at home this season. Indianapolis split its first 2 games as a road favorite, blowing out Tennessee in Week 3, but lost at Pittsburgh in Week 9. Both matchups last season between the Jaguars and Colts were decided by 3 points apiece with the home team winning each time. Jacksonville has won the last 5 home matchup, yet the Jags still an underdog here. We see these teams going in different directions but the Jags look like a public dog in this spot, so we’ll back the Colts.

Colts vs Jaguars prediction: Indianapolis Colts -1.5 (-110) available at time of publishing. Playable to 2.

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Game Totals Pick

Under 47.5(-110)

Reasoning

The last 5 matchups between the Colts and Jaguars have finished over the total. In 2024, Jacksonville outlasted Indianapolis, 37-34 at home, easily going over the total of 44. In the second matchup in Week 18, the Colts escaped past the Jaguars in overtime, 26-23, which hit the over of 45.5. Jacksonville has eclipsed the 31-point mark in 3 of the last 4 matchups, as Jaguars QB Trevor Lawrence started in all 3 of those high-scoring outputs.

This season, each team is 6-6 to the over, and the Colts are 3-2 to the under on the road. Jacksonville is 4-1 to the under at EverBank Stadium, as the lone over came in the Monday night comeback victory against Kansas City in Week 5. In their 5 home games, the Jags have given up 10 or fewer points 3 times, including allowing 6 points in their last home win over the Chargers in Week 11. The Colts are on a 3-1 under run in the past 4 games, while scoring 20 or less points 3 times. In the first 8 games, Indianapolis was held to 20 points once, which came in its first loss to the Rams in Week 4.

The Colts rank 4th in the NFL in yards per game at 375.4, while the Jaguars sit 19th at 326 yards per game. We’ll see how Jacksonville handles Colts RB Jonathan Taylor, who leads the league with 1,282 rushing yards. The Jaguars lead the NFL in rushing yards allowed per game at 82.4, but yielded 177 yards on the ground to Taylor in the Week 18 loss last season. The 47.5 point total is the highest since 2021, and that game remained under the total. This meeting should break the trend of these high-scoring matchups between these AFC South rivals and stay Under the total.

Colts vs Jags prediction: Under 47.5 (-110) available at time of publishing. Playable to 46.5.

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Show Bio

Kevin covers the NFL for Pickswise from sunny south Florida. He has been handicapping the NFL professionally since 2007, as well the NBA, MLB, NHL, college football, and college basketball. He looks forward to a profitable season at Pickswise.

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