Indianapolis Colts vs Pittsburgh Steelers Prediction, Odds and Picks for Sunday, 11/02/25

A pair of AFC division leaders hook up in Pittsburgh on Sunday as the Steelers (4-3) try to snap a two-game losing streak. The Colts (7-1) own the best record in the NFL and have scored the most points with 270 own the biggest point differential at +116. Indianapolis torched Tennessee for the second time this season in a 38-14 rout as 14.5-point home favorites. RB Jonathan Taylor has already bypassed his rushing touchdown total from last season with 12 TDs in eight games, including two more scores against the Titans.

The Steelers look to pick themselves up following consecutive losses to the Bengals and Packers. In last Sunday night’s 35-25 home defeat to Green Bay, Pittsburgh led 16-7 at the half. However, the Pack outscored the Steelers, 28-9 in the second half and Pittsburgh’s defense gave up at least 340 passing yards for a second straight game. QB Aaron Rodgers hasn’t thrown for more than 250 yards in a game this season, but has put up at least 2 TD passes in three straight games.

Pittsburgh is listed as a home underdog for the second straight week, while Indianapolis looks to improve to 5-1 against the spread as a favorite this season. The Colts held off the Steelers, 27-24 last season as 2.5-point home underdogs, beating Pittsburgh for a second straight season. Indianapolis leads the NFL in yards per game, while Pittsburgh ranks 30th in yards allowed per game.

Five of Indianapolis’ seven wins have come against teams with losing records. The two victories over teams with winning records came in the final seconds against the Broncos in Week 2 and a blowout of the Chargers as a road underdog. The public will be all over the Colts in this one, but the Steelers are worth a strong look here to end their slide as a home underdog.

Colts vs Steelers prediction: Steelers +3 (-105) available at time of publishing. Playable at that number.

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