Indianapolis Colts

Indianapolis Colts vs Pittsburgh Steelers Prediction, Odds and Picks for Today, 11/02/25

Acrisure StadiumCBS
Colts
7-1
Colts
Today
Steelers
4-3
Steelers
Pittsburgh Steelers

Colts vs Steelers Pickswise Expert Predictions

Point Spread Pick
PIT Steelers +3.0(-105)

A pair of AFC division leaders hook up in Pittsburgh on Sunday when the Steelers (4-3) will try to snap a 2-game losing streak. The Colts (7-1) own the best record in the NFL and have scored the most points with 270. Moreover, they own the biggest point differential in the league at +116. Indianapolis torched Tennessee for the second time this season in a 38-14 rout as 14.5-point home favorites last week. RB Jonathan Taylor has already bypassed his rushing touchdown total from last season with 12 TDs in 8 games, including 2 more scores against the Titans.

The Steelers look to pick themselves up following consecutive losses to the Bengals and Packers. In last Sunday night’s 35-25 home defeat to Green Bay, Pittsburgh led 16-7 at the half. However, the Pack outscored the Steelers, 28-9 in the second half and Pittsburgh’s defense gave up at least 340 passing yards for a second straight game. QB Aaron Rodgers hasn’t thrown for more than 250 yards while wearing the black and gold yet, but has put up at least 2 TD passes in 3 straight games.

Pittsburgh is listed as a home underdog for the 2nd straight week, while Indianapolis looks to improve to 5-1 against the spread as a favorite this season. The Colts held off the Steelers, 27-24 last season as 2.5-point home underdogs, beating Pittsburgh for a 2nd straight season. Indianapolis leads the NFL in yards per game, while Pittsburgh ranks 30th in yards allowed per game.

Five of Indianapolis’ 7 wins have come against teams with losing records. The two victories over teams with winning records came in the final seconds against the Broncos in Week 2 and a blowout of the Chargers as a road underdog. The public will be all over the Colts in this one, but the Steelers are worth a strong look here to end their slide as a home underdog.

Colts vs Steelers prediction: Pittsburgh Steelers +3 (-105) available at time of publishing. Playable at that number.

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Kevin Rogers
Game Totals Pick
Under 50.5(-110)

Both Indianapolis and Pittsburgh have been strong over teams this season. The Colts are 5-3 to the over, while the Steelers are 5-2. Pittsburgh’s defense has been responsible for the latest string of overs, allowing 33 points to Cincinnati and 35 points to Green Bay the past 2 losses. Meanwhile, Indianapolis’ offense has produced 31 or more points in 6 games, but has given up at least 20 points in all 3 road contests.

In last season’s matchup in Indianapolis, the Colts held off a late Steelers’ rally in a 27-24 victory, easily going over the total of 41. Sunday’s total has shot up to 50.5, but it is worth noting that Justin Fields and Joe Flacco started that game. As we know, both are with different teams this season. Pittsburgh hasn’t seen a total of at least 50 since the 2020 season. There’s been one total in the 50s for Indianapolis this season, which stayed under in its lone loss to the Rams, 27-20 in Week 4.

QB Daniel Jones has thrown 9 TDs the last 4 games for the Colts. In 5 of the last 6 games, the Steelers have allowed at least 2 TD passes, which doesn’t seem sustainable. Pittsburgh is averaging 21.6 points per game at Acrisure Stadium, compared to 27.5 ppg on the road and in its one game in Dublin. It’s easy to think Indianapolis will continue to roll offensively and Pittsburgh will keep struggling defensively. However, with this being Pittsburgh’s highest total in almost 5 seasons, the under is worth a strong look here.

Colts vs Steelers pick: Under 50.5 (-110) available at time of publishing. Playable at that number.

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Kevin Rogers
Kevin covers the NFL for Pickswise from sunny south Florida. He has been handicapping the NFL professionally since 2007, as well the NBA, MLB, NHL, college football, and college basketball. He looks forward to a profitable season at Pickswise.
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Top Trends
Money Line

The Steelers have won four straight home games against the Colts

Game Totals

The Colts' last three games have gone over the Total

Point Spread

The Colts are 4-1 ATS in their last five games as a favourite

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