HomeNFLNFL PredictionsIndianapolis Colts vs Seattle Seahawks Predictions, Odds & Expert Picks for NFL Week 15 2025

Indianapolis Colts vs Seattle Seahawks Predictions, Odds & Expert Picks for NFL Week 15 2025 for Today, 12/14/25

Updated: 4:52 AM ET Dec 14, 2025

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Colts

4:25 PM ETToday

Seahawks

LWLLL	Last 5	WLWWW
8-5	Record	10-3
7-5-1	ATS Record	10-3-0
7-6	O/U Record	8-5

Colts vs Seahawks Pickswise Expert Predictions

Point Spread Pick

SEA Seahawks -13.5(-110)

Reasoning

If anyone had Phillip Rivers playing a game this season on their bingo card, I’d like to know their Super Bowl pick! The 44-year-old QB was signed to the Colts’ practice squad this week, and it will either be him or rookie QB Riley Leonard under center for Indy this Sunday. Neither option is pretty for a Colts team that has dropped 3 of 4 and is slowly falling out of the AFC playoff picture. Losing QB Daniel Jones to an Achilles injury was a brutal blow for this squad, but Indiana Jones was already playing with an injured fibula, which had greatly affected the Colts offense. Indianapolis is averaging just 3.7 yards per rushing attempt in their last 3 games (23rd), which has been a big drop off from their 5.0 yards per carry average over the entire season (4th in the NFL).

On the flip side, this Seahawks team is firing on all cylinders. After a slow start in Week 14 against the Falcons, they outscored Atlanta 31-3 in the second half en route to a 37-9 victory. Seattle has now won 7 of their last 8 games, with their only defeat coming at the Rams, 21-19. QB Sam Darnold has been elite this year, as the Seattle passing offense is averaging 8.9 yards per pass attempt (1st in the NFL), leading to 29.8 points per game (2nd in the NFL). A big story to watch will be whether Colts CB Sauce Gardner plays on Sunday because he missed last week’s loss to the Jags and didn’t practice on Wednesday due to a calf injury. The pass defense clearly struggled without Sauce, as Trevor Lawrence averaged 8.1 yards per pass attempt, which is much higher than the Colts’ season average (6.6).

The spread is huge, but I can’t find any reason to back the Colts in this one. Under Mike Macdonald, Seattle has been a 7+ point favorite 3 times at home, and they’ve won those games by 26, 22 and 31. Additionally, Sam Darnold has been a favorite of 6+ points 11 times as a starter, and he is 9-2 ATS in those games. Things won’t get easier for this Colts team, no matter who is under center, so give me Seattle in a blowout win.

Colts vs Seahawks prediction: Seattle Seahawks -13.5 (-110) available at the time of publishing, playable at that number.

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Game Totals Pick

Under 42.5(-110)

Reasoning

The total for this game is tough to choose, but I have zero confidence in this Colts offense to put up points. We saw Riley Leonard last week, and the rookie QB threw for just 145 yards and 1 interception. Although he found the end zone with his legs, it came during garbage time when the Jags were already leading 36-13. Even if Rivers is under center, I can’t see things improving too much. The 44-year-old would be going up against a Seahawks defense that’s allowing just 5.4 yards per pass attempt (1st in the NFL) and 3.8 rushing yards per carry (2nd in the NFL). Although the Houston Texans are getting plenty of accolades as the league’s best defense, this Seattle D is quietly having an elite season.

On the flip side, this Indianapolis defense will need to get stops if they want to have any chance in this game. The good news is that they’re also allowing just 3.8 yards per rush attempt this season and have held elite offenses like the Chiefs and Rams to 23 and 27 points. Now, I will admit that Seattle scoring 40+ is my biggest worry for this game going over the total, but I imagine that they’ll be able to take their foot off the gas by the end of the third quarter. With little to believe in this Colts offense, give me the under in Seattle on Sunday afternoon.

Colts vs Seahawks prediction: Under 42.5 (-110) available at the time of publishing, playable at that number.

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Show Bio

Luke Lindholm is the North American Content Editor for Spotlight Sports Group (SSG) and is living in Boston, Massachusetts. Luke has been handicapping the NFL, NCAAF, MLS, and other major Soccer tournaments since 2021 and loves sharing knowledge with other knowledgeable handicappers in the sports betting industry. For Luke Lindholm media enquiries, please email contact@pickswise.com.

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Point Spread

The Seahawks have covered the spread in 4 of their last 5 games at home.

Game Totals

The Over is 8-5 in Seahawks' games this season.

Money Line

The Seahawks have won 4 of their last 5 games at home, while the Colts have lost on 3 straight road trips.

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