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Jacksonville Jaguars

Jacksonville Jaguars vs Arizona Cardinals Predictions, Odds & Expert Picks for NFL Week 12 2025 for Today, 11/23/25

State Farm StadiumCBS
Jaguars
Jaguars
Today
Cardinals
Cardinals
LLWLW
Last 5
LLWLL
6-4Record3-7
5-5-0ATS Record5-5-0
5-5O/U Record6-4
Arizona Cardinals

Jaguars vs Cardinals Best Bets

Point Spread PickBest Bet
JAX Jaguars -2.5(-112)

The Arizona Cardinals have lost 7 of their last 8 games heading into a home date with the Jacksonville Jaguars during Week 12 of the NFL season on Sunday afternoon. Once 2-0, the Cardinals are now 3-7 and aren’t even looking competitive. They have dropped 2 consecutive contests by at least 19 points. Arizona is only a slight underdog against Jacksonville because it is playing at home, but does that really matter? Probably not! After all, the Cards have lost 4 home games in a row – including to the lowly Titans. Tennessee (1-9) has not won a single other game this entire year. This is simply a fantastic time to fade head coach Jonathan Gannon’s squad, so my Jaguars vs Cardinals pick is on the visitors to win and cover.

Jacksonville, on the other hand, is playing solid football. Its worst loss since Week 2 is against the Texans, but even a 1-possession setback on the road in Houston is nothing to be ashamed about. The Jaguars are coming off a 35-6 beatdown of the Chargers this past weekend. It is true that the Bolts’ offensive line is in absolute shambles, but that is still an extremely impressive result any way you slice it. The Jags churned out 192 rushing yards, which bodes well for their chances of finding success against a mediocre Cardinals defense. This is a tale of 2 teams going in opposite directions, and I think that trend will continue on Sunday.

Jaguars vs Cardinals prediction: Jacksonville Jaguars -2.5 (-112) available at time of publishing. Playable to -3.

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Ricky Dimon

Jaguars vs Cardinals Pickswise Expert Predictions

Game Totals Pick
Over 47.5(-105)

The Cardinals have given up more than 40 points in back-to-back outings; the Jaguars are averaging more than 30 over their last 3 contests. It’s safe to say that none of that is encouraging for Arizona’s defense heading into Sunday’s matchup. As such, my Jaguars vs Cardinals pick is over 47.5.

Jacksonville running back Travis Etienne has scored 3 touchdowns on the ground over the past 2 games and he is now facing an Arizona defense that has surrendered 11 rushing TDs in 2025 (tied for the 9th-most in the league). Quarterback Trevor Lawrence has thrown too many interceptions this season (8), but half of those came in the first 3 weeks.

If there is any good news for the Cards, it’s that Jacoby Brissett is filling in decently enough for Kyler Murray – who is out with an ankle injury and not expected to start again in 2025. Brissett just torched San Francisco for 452 yards on 47-of-57 passing to go along with 2 touchdowns. His TD-to-INT ratio through 5 starts this season is 10-to-3, including 8-to-2 over the past 4 outings. Brissett now faces a Jacksonville defense that is #26 in the NFL against the pass and has allowed the fourth-most touchdowns through the air.

Jaguars vs Cardinals prediction: Over 47.5 (-105) available at time of publishing. Playable at that number.

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Ricky Dimon
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Ricky Dimon

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.
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Game Totals

7 of the Cardinals' last 8 home games have gone Over the total.

Point Spread

The Jaguars have failed to cover the spread in their last 4 games as a road favorite.

Money Line

The Cardinals have lost 7 of their last 10 games.

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