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Los Angeles Chargers

Los Angeles Chargers vs Dallas Cowboys Prediction, Odds and Picks for Sunday, 12/21/25

AT&T StadiumFOX
Chargers
10-4
Chargers
Sun Dec 21
Cowboys
6-7-1
Cowboys
Dallas Cowboys
Google News

Chargers vs Cowboys Guest Expert Predictions

Point Spread Pick
LA Chargers +2.5(-112)

The Cowboys (6-7-1) were on the verge of salvaging their season with a 3-game winning streak to finish off November, capped off by a home-underdog victory over the Chiefs. However, Dallas allowed 77 points in the past 2 losses to Detroit and Minnesota to fall below .500 and 3 games behind Philadelphia in the NFC East. The Cowboys will try to rebound from a 34-26 home defeat to the Vikings last Sunday night when the red-hot Chargers visit on Sunday.

Los Angeles (10-4) seeks its 4th straight win and 6th victory in the past 7 tries. The Chargers are back on the road after pulling off the season sweep of the Chiefs 16-13 as 6-point underdogs. Not only did L.A. knock Kansas City out of playoff contention, but the Lightning Bolts are part of a 5-team class in the AFC with at least 10 wins. It marked the 4th victory for Jim Harbaugh’s club by 3 or fewer points, while allowing fewer than 19 points for the 3rd consecutive week.

This is the home finale for the Cowboys, who wrap up the regular season on the road against the Commanders and Giants. Dallas has struggled in the role of a home favorite, going 1-3 against the spread, compared to a perfect 3-0 ATS mark as a home underdog. The Chargers have covered and won in all 3 opportunities as an underdog this season, while not giving up more than 21 points in any of those games. The Cowboys scored 2 early TDs against Minnesota, but didn’t reach the end zone over almost the entire final 3 quarters. This pick isn’t about riding the trends, but Dallas proved it has struggled as a favorite, while L.A. has thrived in the ‘dog role.

Chargers vs Cowboys prediction: Los Angeles Chargers +2.5 (-112) available at time of publishing. Playable to +2.

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Game Totals Pick
Under 49.5(-105)

These teams have gone in different directions from a totals standpoint this season. Dallas has been one of the top over teams at 10-4, including 3 consecutive overs. The Cowboys’ defense is reverting back to their early season numbers, allowing 28, 44, and 34 points in the past 3 games. On the flip side, the Chargers have given up 20 or fewer points in 5 of the previous 6 outings, including an average of 15.3 ppg the past 3 weeks. Los Angeles is currently on a 4-1 under run, including under in the last 2 road games.

The Chargers are looking at their highest total of the season at 49.5, as their previous high was 49 against the Colts in Week 7. Los Angeles fell at home to Indianapolis 38-24, which hit the over, but the Lightning Bolts are 4-2 to the under on the road. In 4 of 6 away contests, L.A. has been held to 20 or less points, while not reaching 30 points on the road this season. The Cowboys are 5-2 to the over at home, while posting a 6-2 over mark on totals below 50. Dallas is 5-1 to the over off a loss with the lone under coming on a 53.5 total in a 27-17 setback to Arizona in Week 9.

Los Angeles has faced 3 QBs in the Top 10 of passing yards this season, taking on Denver’s Bo Nix, Jacksonville’s Trevor Lawrence, and Kansas City’s Patrick Mahomes twice. The Chargers allowed exactly 153 passing yards in each of those first 2 games, beating the Broncos and losing to the Jaguars. Mahomes threw for 258 yards in the opening week loss in Brazil before being held to 189 yards last week. Dallas QB Dak Prescott leads the NFL in passing yards, but has been limited to 1 TD pass in the past 2 losses. The Chargers are terrific defensively and can win a grind-it-out game, even against the offensive prowess of the Cowboys.

Chargers vs Cowboys prediction: Under 49.5 (-105) available at time of publishing. Playable to 49.

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Ricky Dimon

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.
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