Los Angeles Chargers vs Kansas City Chiefs Prediction, Odds and Picks for Sunday, 12/14/25

One of the most important matchups of the weekend in the NFL comes in Kansas City, where the Chiefs will host the Chargers in what is now a de-facto elimination game for Kansas City. A season ago, the Chiefs were basically perfect in one-score games all season long, until they reached the Super Bowl and were embarrassed by the Eagles. Since that point, Andy Reid’s bunch has floundered in close games this season, with much of their current predicament stemming from the fact that they are just 1-6 in games decided by one possession. Unlike the 2024 campaign, this Chiefs team is actually due for some positive regression, and I’m of the opinion that Kansas City’s bid for another playoff berth will continue for at least a few more weeks.

Despite their rampant offensive line issues and a run game that has basically been nonexistent for most of the year, this is still an offense led by Patrick Mahomes that is surprisingly 4th in DVOA on the season. They’re also finally in a good situational spot this week against a Chargers team that is coming off the biggest win of their season and will be traveling to Kansas City on a short week. Given the fact that temperatures are expected to be well below freezing and we should see some sustained wind in this game, it’s hard to see Justin Herbert seeing much success with his broken left hand in the blistering cold. The Chargers offensive line is a revolving door at the moment, and they just allowed a whopping 72% pressure rate against the Eagles on Monday. That doesn’t bode well for a matchup against a Kansas City defensive front that is coming off a very strong game against Houston a week ago. The Chargers’ game plan is one that is going to involve a heavy dose of the run game and a ton of deep shots, and Kansas City has done very well in both of those areas of late — with the Chiefs ranking 8th against the run over the last 5 weeks. All things considered, this should be a game where Kansas City flexes its muscles en route to a victory by at least a touchdown at home.

Chargers vs Chiefs prediction: Chiefs -4.5 available at time of publishing. Playable to -5.5

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Chargers vs Chiefs predictions.