HomeNFLNFL PredictionsLos Angeles Chargers vs Kansas City Chiefs Predictions, Odds & Expert Picks for NFL Week 15 2025

Los Angeles Chargers vs Kansas City Chiefs Predictions, Odds & Expert Picks for NFL Week 15 2025 for Today, 12/14/25

Updated: 1:52 AM ET Dec 14, 2025

Arrowhead StadiumCBS

Chargers

1:00 PM ETToday

Chiefs

WWLWW	Last 5	LLWLL
9-4	Record	6-7
7-6-0	ATS Record	5-8-0
6-7	O/U Record	4-9

Chargers vs Chiefs Pickswise Expert Predictions

Point Spread Pick

KC Chiefs -4.5(-110)

Reasoning

One of the most important matchups of the weekend in the NFL comes in Kansas City, where the Chiefs will host the Chargers in what is now a de facto elimination game for Kansas City. A season ago, the Chiefs were basically perfect in 1-score games all season long, until they reached the Super Bowl and were embarrassed by the Eagles. Since that point, Andy Reid’s bunch has floundered in close games this season, with much of their current predicament stemming from the fact that they are just 1-6 in games decided by 1 possession. Unlike the 2024 campaign, this Chiefs team is actually due for some positive regression, and I’m of the opinion that Kansas City’s bid for another playoff berth will continue for at least a few more weeks.

Despite their rampant offensive line issues and a run game that has basically been nonexistent for most of the year, this is still an offense led by Patrick Mahomes that is surprisingly 4th in DVOA on the season. They’re also finally in a good situational spot this week against a Chargers team that is coming off the biggest win of their season and will be traveling to Kansas City on a short week. Given the fact that temperatures are expected to be well below freezing and we should see some sustained wind in this game, it’s hard to see Justin Herbert seeing much success with his broken left hand in the blistering cold. The Chargers offensive line is a revolving door at the moment, and they just allowed a whopping 72% pressure rate against the Eagles on Monday. That doesn’t bode well for a matchup against a Kansas City defensive front that is coming off a very strong game against Houston a week ago. The Chargers’ game plan is one that is going to involve a heavy dose of the run game and a ton of deep shots, and Kansas City has done very well in both of those areas of late — with the Chiefs ranking 8th against the run over the last 5 weeks. All things considered, this should be a game where Kansas City flexes its muscles en route to a victory by at least a touchdown at home.

Chargers vs Chiefs prediction:Kansas City Chiefs -4.5 available at time of publishing. Playable to -5.5.

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Game Totals Pick

Under 42.5(-110)

Reasoning

Regardless of which team wins this game, the under is one of my favorite totals of the week — and for good reason. As previously mentioned, both teams have really struggled with protecting the quarterback and that certainly shouldn’t change on Sunday. Los Angeles’ offense was largely inept against Philadelphia, and it took 5 turnovers from the Eagles for the Chargers to emerge victorious. Herbert should be in for another long afternoon against a Chiefs front that just played a very strong game a week ago and should be primed to put forth its most focused effort in what is a must-win game for Kansas City. On the other side, Kansas City’s offense has been up-and-down all season long, and while the Chiefs are due for some positive turnover and late down regression, the Chargers defense is still a top-10 unit across the league and should be able to keep Kansas City to 24 points or fewer. Let’s look to the under in what should be a brutally cold game in Kansas City.

Chargers vs Chiefs prediction: Under 42.5 available at time of publishing. Playable to 41.5.

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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.

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