HomeNFLNFL PredictionsLos Angeles Rams vs Arizona Cardinals Predictions, Odds & Expert Picks for NFL Week 14 2025

Los Angeles Rams vs Arizona Cardinals Predictions, Odds & Expert Picks for NFL Week 14 2025 for Sunday, 12/07/25

Updated: 11:51 AM ET Dec 04, 2025

State Farm StadiumFOX

Rams

4:25 PM ETSun Dec 7

Cardinals

WWWWL	Last 5	WLLLL
9-3	Record	3-9
8-4-0	ATS Record	6-6-0
5-7	O/U Record	7-5

Rams vs Cardinals Pickswise Expert Predictions

Point Spread Pick

LA Rams -8.0(-110)

Reasoning

Hell hath no fury like a Super Bowl favorite scorned. The Rams had won 6 straight and were clear favorites to win the Vince Lombardi Trophy heading into Week 13, but were rocked by a 31-28 upset against the Carolina Panthers. While LA remains at the top of the Super Bowl betting market, that defeat will no doubt have irked Sean McVay and quarterback Matt Stafford, who will be looking to get back on track in a big way and should deliver a statement win over the Cardinals. Stafford has already been phenomenal this season, throwing 32 touchdowns (by far the most in the NFL) to just 4 interceptions, with 2+ TD passes in 8 of his last 9 games. He should be able to carve through a Cardinals defense that ranks in the bottom half of the NFL against the pass.

Despite being 3-9, Arizona has actually been fairly competitive at times this season, pushing playoff contenders Tampa Bay, Jacksonville, Green Bay and Indianapolis all the way while also picking up a surprise win over the Cowboys at AT&T Stadium. While the Cardinals offense has been solid behind Jacoby Brissett, their turnstile defense is what has let them down, allowing 27+ points in 5 of their last 7 games. Given how red hot the Rams are this season and the desire of Stafford, Puka Nacua and Kyren Williams to right last week’s wrong, expect LA to earn a big victory over Arizona.

Rams vs Cardinals prediction: Rams -8 (-110) available at time of publishing. Playable to 9.

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Game Totals Pick

Over 47.5(-110)

Reasoning

Given the strength of the Rams’ offense this season and the fact that the Cardinals have actually been quite positive in moving the ball lately, this total looks a touch too low. LA has put up 34+ points in 4 of their last 6 games and now gets to take on an Arizona team that has allowed 41+ in 2 of its last 4 games, in addition to allowing Brock Purdy and Trevor Lawrence to throw 3 touchdown passes in that period. That doesn’t set up well for a defense about to welcome an angry Matt Stafford desperate to muscle his way back to the top of the MVP betting board, especially with the Patriots on a bye. Defenses have had no answer for the Puka Nacua-Davante Adams tandem, and that is unlikely to change here.

While LA’s defense has been solid, it has been prone to allowing points in recent weeks. Giving up 31 to the Panthers last week as Bruce Young threw 3 TD passes highlighted some of the Rams’ vulnerability on that side of the ball, while the 49ers twice put 26 on them. The Cardinals have posted the 5th-most passing yards in the NFL this season, so Brissett and company should have some success moving the ball and putting points on the board. With both teams capable of scoring, let’s ride the over in this one.

Rams vs Cardinals pick: Over 47.5 (-110) available at time of publishing. Playable to 48.5.

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Managing Editor of Pickswise. Born and raised in jolly old London, England, with an undying love for the NFL, NBA, soccer and horse racing. A big-time sports bettor who loves futures markets and backing underdogs. Long-suffering New York Jets fan. For Andrew Wilsher media enquiries, please email contact@pickswise.com.

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