Los Angeles Rams vs Jacksonville Jaguars Prediction, Odds and Picks for Sunday, 10/19/25

The next London game on the NFL slate is this Week 7 matchup between the Los Angeles Rams and Jacksonville Jaguars in a battle of 4-2 teams. Jacksonville was riding high off its signature primetime win over the Chiefs, and then came crashing back down to earth last week in a loss to the Seahawks. While I don’t think the Jags were ever as good as their 4-1 record suggested, I also don’t think the Rams deserve to be 3-point favorites here.

The Jaguars’ loss to Seattle has more to do with the Seahawks just being a legitimately-good team than anything else, and I’m not overreacting after 1 week – just like I wasn’t overreacting after their win over Kansas City. Liam Coen has something cooking, and the ground game is back with Travis Etienne averaging 5.3 yards per carry. I haven’t been all too impressed by the Rams even though Matthew Stafford has played at a high level, and I’m not giving them much credit at all for beating a Cooper Rush-led Ravens team last week.

Just the week before, the Rams lost to Mac Jones at home. Los Angeles’ 4 wins this season have come against a Texans team that started the year terribly, an awful Titans team, the Colts in a fluky game where Indy blew the game by dropping the ball at the goal line, and then Rush last week. The Jaguars have played in London a ton in recent years and they played there twice last year, so they won’t have to make nearly as much of an adjustment as the Rams and should acclimate better. Give me the underdog in this spot.

Rams vs Jaguars best bets: Jacksonville Jaguars +3 available at time of publishing. Playable to 1.5.

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $200 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Rams vs Jaguars predictions.

I also think the over makes some sense here. The Rams have played a pretty soft slate of opposing offenses, and the couple of times they’ve been tested against competent offenses, other teams have been able to consistently move the ball on them. I wouldn’t read too much into their low-scoring game last week, they got out to an early lead and were able to just run out the clock knowing Cooper Rush wasn’t going to lead the Ravens to any points.

The week before, they gave up 26 points to a 49ers offense led by Mac Jones who was playing on the road on a short week. Jones threw for 342 yards like it was 2021 again, so I think Trevor Lawrence will be able to have some success here. On the other side of the ball Matthew Stafford is aging like a fine wine, with 12 touchdowns and only 2 interceptions. He’s averaging over 8 yards per attempt and Puka Nacua is averaging over 100 yards per game.

Rams vs Jags prediction: Over 44.5 (-110) available at time of publishing. Playable to 45.5.

Bet like a Caesar with this AMAZING new customer offer from Caesars Sportsbook. If you bet just $1, you’ll receive DOUBLE YOUR WINNINGS on your next 20 bets! Become a Caesars member 👥 using the Caesars promo code PWCONTENT20X, where you can bet on our Rams vs Jaguars picks.