Los Angeles Rams

Los Angeles Rams vs San Francisco 49ers Prediction, Odds and Picks for Today, 11/09/25

Levi's StadiumFOX
Rams
Rams
Today
49ers
49ers
WLWWW
Last 5
WLWLW
6-2Record6-3
6-2-0ATS Record5-4-0
3-5O/U Record5-4
San Francisco 49ers

Rams vs 49ers Pickswise Expert Predictions

Point Spread Pick
LA Rams -4.5(-110)

The last time the Rams and 49ers got together in Los Angeles in Week 5, it turned into one of the wildest games of the season. San Francisco blew an early 14-0 lead, as Los Angeles rallied back to force overtime tied at 23-23. The 49ers kicked the go-ahead field goal on their first drive in OT, followed by stuffing the Rams on 4th and 1 to close out a 26-23 win as 8.5-point underdogs. QB Mac Jones torched the Rams defense for 342 yards and 2 touchdowns to end a 3-game losing streak to Los Angeles dating back to 2023.

The race for first place in the NFC West down the stretch will be a good one, as Seattle and Los Angeles are tied at 6-2 with San Francisco right behind at 6-3. The Rams are riding a 3-game winning streak since that heartbreaking loss to the 49ers, coming off a 34-10 blowout of the hapless Saints last Sunday as a 14.5-point favorite. Los Angeles could have easily won the 2 games it lost, starting in Philadelphia in Week 3 when the Rams squandered a 26-7 lead in a 33-26 defeat.

San Francisco has alternated wins and losses in each of the 7 games, as the 49ers cruised past the Giants last Sunday, 2.5-point road favorites. Kyle Shanahan’s team is 1-4 against the spread this season following a win, while giving up at least 26 points in the last 3 games off a victory. The 49ers have intercepted 1 pass the whole season, while Rams QB Matthew Stafford has thrown only 2 interceptions. The Rams have won and covered in all 3 victories away from SoFi Stadium, while winning each of the last 2 visits to Santa Clara. After coming out flat early against the 49ers in the first matchup as a heavy favorite, this is a good buy-low spot on the Rams as a short road favorite.

Rams vs 49ers prediction: Los Angeles Rams -4.5 (-110) available at time of publishing. Playable to 5.

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Kevin Rogers
Game Totals Pick
Under 49.5(-110)

The first matchup between these NFC West rivals was on its way to an under before Joshua Karty’s game-tying field goal with no time remaining in regulation forced overtime in Week 5. The 49ers eventually won, 26-23 to cash the over of 44, as the total in Sunday’s rematch at Levi’s Stadium has jumped to 49.5. The Rams are 4-3-1 to the under this season, while the 49ers are 5-3-1 to the over. San Francisco is 2-1 to the under at home and its Week 4 loss to Jacksonville went over by one point on a 46 total.

In the 2nd matchup between the Rams and 49ers over the last 3 seasons, the combined scores have been 18, 41, and 45 points. In 3 of 4 games away from SoFi Stadium, the Rams allowed 19 or fewer points. Los Angeles limited Philadelphia to 7 points in the first half before the Eagles scored 26 points in the second half. The Rams have given up 20 points in the past 3 victories since allowing 26 points to the 49ers.

QB Mac Jones averaged 313 passing yards in each of his first 4 starts after taking over for the injured Brock Purdy. However, Jones has put up 193.3 yards per game in each of the past 3 contests for the 49ers. RB Christian McCaffrey has racked up over 100 rushing yards in 2 of the last 3 games, while being held to 52 or fewer yards in 2 home games in September. This game should go under this adjusted high total after the Rams limited the 49ers to 4 field goals in the final 50 minutes in the first matchup.

Rams vs 49ers pick: Under 49.5 (-110) available at time of publishing. Playable to 48.5.

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Kevin Rogers
Managing Editor of Pickswise. Born and raised in jolly old London, England, with an undying love for the NFL, NBA, soccer and horse racing. A big-time sports bettor who loves futures markets and backing underdogs. Long-suffering New York Jets fan. For Andrew Wilsher media enquiries, please email contact@pickswise.com.
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Top Trends
Point Spread

The Rams have covered the spread in 9 of their last 11 games (82%) as a favorite.

Money Line

The 49ers have won their last 3 matchups against divisional opponents.

Game Totals

The Under is 4-1 in the Rams' last 5 games.

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