New Orleans Saints vs Carolina Panthers Prediction, Odds and Picks for Sunday, 11/09/25

It will battle in the NFC South when the New Orleans Saints and Carolina Panthers collide in Week 10 of the NFL season on Sunday afternoon at Carolina. The Panthers (5-4) have been better than expected so far. Unfortunately for the Saints, they have been just as advertised–terrible. They are 1-8 and their lone win has come in a game in which the other team (the Giants) committed a ridiculous 5 turnovers and forced none. In other words, the Saints should be 0-9. Now they have to face an opponent that just beat Green Bay at Lambeau Field. Yeah, I’m not envisioning this game being competitive at all. My Saints vs Panthers pick is on the home side to win and cover.
 
New Orleans started the season in bad form and has actually gotten worse. First-year head coach Kellen Moore’s crew has not kept a game within 12 points since Week 6 and its 2 most recent losses have come by a combined margin of 57-13. Rookie quarterback Tyler Shough got his first NFL start this past weekend Sunday and the Saints’ offense was predictably inept during a 34-10 blowout by the Rams. Shough threw for 176 yards with 1 touchdown and 1 interception. Meanwhile, Carolina has won 4 of its last 5 games and its only home loss this season is to a high-powered Buffalo outfit. Give me the Panthers to win big.

New Orleans Saints vs Carolina Panthers prediction: Panthers -5.5 (-108) available at time of publishing. Playable to -7.

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