New Orleans Saints

New Orleans Saints vs Carolina Panthers Prediction, Odds and Picks for Sunday, 11/09/25

Bank of America StadiumFOX
Saints
1-8
Saints
Sun Nov 9
Panthers
5-4
Panthers
Carolina Panthers
Google News

Saints vs Panthers Pickswise Expert Predictions

Point Spread PickBest Bet
CAR Panthers -5.5(-108)

It will battle in the NFC South when the New Orleans Saints and Carolina Panthers collide in Week 10 of the NFL season on Sunday afternoon at Carolina. The Panthers (5-4) have been better than expected so far. Unfortunately for the Saints, they have been just as advertised–terrible. They are 1-8 and their lone win has come in a game in which the other team (the Giants) committed a ridiculous 5 turnovers and forced none. In other words, the Saints should be 0-9. Now they have to face an opponent that just beat Green Bay at Lambeau Field. Yeah, I’m not envisioning this game being competitive at all. My Saints vs Panthers pick is on the home side to win and cover.
 
New Orleans started the season in bad form and has actually gotten worse. First-year head coach Kellen Moore’s crew has not kept a game within 12 points since Week 6 and its 2 most recent losses have come by a combined margin of 57-13. Rookie quarterback Tyler Shough got his first NFL start this past weekend Sunday and the Saints’ offense was predictably inept during a 34-10 blowout by the Rams. Shough threw for 176 yards with 1 touchdown and 1 interception. Meanwhile, Carolina has won 4 of its last 5 games and its only home loss this season is to a high-powered Buffalo outfit. Give me the Panthers to win big.

New Orleans Saints vs Carolina Panthers prediction: Panthers -5.5 (-108) available at time of publishing. Playable to -7.

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Ricky Dimon
Game Totals Pick
Under 39.5(-102)

I don’t like this play nearly as much as the side, but my other Saints vs Panthers pick is Under 39.5. New Orleans’ offense has struggled all season long and it is probably even worse with Shough under center compared to Spencer Rattler. The Saints’ 138 total points scored so far this year are dead last in the NFC. Carolina’s defense is slightly worse against the run than it is against the pass, but there is no reason to think that New Orleans will be able to capitalize. Running back Alvin Kamara has done nothing in 2025; he has gone 5 straight games without rushing for more than 31 yards and he has not scored a single touchdown since the season opener. Kamara is also questionable for Sunday due to an ankle injury.

The Panthers’ offense has been hit or miss so far this year — miss most often in recent weeks. The are averaging an anemic 12.7 points per game over the past 3 outings. QB Bryce Young has reached the 200-yard mark only once through 9 weeks. I don’t have much confidence in either of these 2 NFC South offenses. That being said, I can’t put a ton of confidence behind this play when the total is sub-40.

New Orleans Saints vs Carolina Panthers prediction: Under 39.5 (-102) available at time of publishing. Playable at that number.

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Ricky Dimon
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Ricky Dimon

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.
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