New Orleans Saints vs Tampa Bay Buccaneers Prediction, Odds and Picks for Sunday, 12/07/25

This isn’t exactly the most compelling game on the Week 14 slate, but the Buccaneers are in decent position to finally pick up a win by margin after struggling over the last 6 weeks. Tampa Bay is still dealing with a ton of injuries on offense, but the Buccaneers should be a bit healthier on the offensive line and in the wide receiving corps. It certainly helps matters that Baker Mayfield has performed at a very high level at home this season, and he’ll be facing a defense that he’s already seen once this season, and that was when Tampa Bay was extremely banged-up. On the other side of the ball, Todd Bowles has been a coach that has dominated inexperienced quarterbacks historically, and that’s exactly what the Tampa Bay defense will see here against Tyler Shough, who has struggled mightily against the blitz in his first few starts as an NFL quarterback.

Given the mismatch at hand and the coaching edge that Tampa Bay has in this game, I can’t see the Saints generating consistent success on offense. After all, New Orleans mustered up just 3 points in the first meeting between these teams, and that was in the Superdome. The Bucs won that contest by a whopping 20 points and while we can’t project a similar result in this spot, it’s hard to imagine New Orleans’ meager offense doing enough to stay within this number on the road. It’s not my favorite game on the card, but I’ll lay the points with Tampa Bay.

Saints vs Buccaneers prediction: Bucs -8 available at time of publishing. Playable to -8.5

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