New York Giants vs Detroit Lions Prediction, Odds and Picks for Sunday, 11/23/25

We have a fascinating NFL Week 12 matchup on our hands on Sunday, as the New York Giants head to Detroit to take on the Lions at Ford Field. This game isn’t all that appealing on paper, but the situational spot is pretty advantageous for the Lions. On the surface, Detroit looks quite vulnerable following a pair of poor performances against the Vikings and Eagles in recent weeks. However, the Lions are now back home and have a favorable matchup at hand against a Giants team that is one of the worst teams in football, and is dealing with injuries at multiple key positions heading into this game. The biggest question mark coming into this contest is the status of Jaxson Dart, who missed last week’s contest against the Packers with a concussion. The Ole Miss product returned to practice on Wednesday, which makes it very possible that he’d start in Sunday’s game. However, given the fact that Dart likely won’t be running the ball all that much, it’s hard to quantify how helpful he’ll truly be in lifting an offense that is 20th in EPA per play and 25th in success rate. 

Despite the fact that they were just completely shut down by the Eagles stout defense a week ago, the Lions offense has been a well-oiled machine for the majority of the season, as Detroit sits at 5th in EPA per play and 4th in success rate. There are plenty of avenues for Detroit to score in this game, and it all starts on the ground for Dan Campbell’s group. That success running the football should continue against a leaky Giants defense that is dead last in both EPA per rush allowed and in explosive runs allowed. If the Lions are able to jump out to an early lead, that could spell major trouble for a Giants team that isn’t really equipped to play from behind given its current uncertainty at quarterback. I’ll lay the points with the home team in what should be a smash spot for Detroit. 

Giants vs Lions prediction: Lions -10 available at time of publishing. Playable at that number.

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