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New York Giants

New York Giants vs Detroit Lions Predictions, Odds & Expert Picks for NFL Week 12 2025 for Today, 11/23/25

Ford FieldFOX
Giants
Giants
Today
Lions
Lions
LLLLL
Last 5
LWLWL
2-9Record6-4
6-5-0ATS Record6-4-0
6-5O/U Record5-5
Detroit Lions

Giants vs Lions Pickswise Expert Predictions

Point Spread Pick
DET Lions -10.0(-110)

We have a fascinating NFL Week 12 matchup on our hands on Sunday, as the New York Giants head to Detroit to take on the Lions at Ford Field. This game isn’t all that appealing on paper, but the situational spot is pretty advantageous for the Lions. On the surface, Detroit looks quite vulnerable following a pair of poor performances against the Vikings and Eagles in recent weeks. However, the Lions are now back home and have a favorable matchup at hand against a Giants team that is one of the worst teams in football and dealing with injuries at multiple key positions heading into this game. The biggest question mark coming into this contest is the status of Jaxson Dart, who missed last week’s contest against the Packers with a concussion. The Ole Miss product returned to practice on Wednesday, which makes it very possible that he’ll start in Sunday’s game. However, given the fact that Dart likely won’t be running the ball all that much, it’s hard to quantify how helpful he’ll truly be in lifting an offense that is 20th in EPA per play and 25th in success rate. 

Despite the fact that they were just completely shut down by the Eagles stout defense a week ago, the Lions offense has been a well-oiled machine for the majority of the season – as Detroit sits at 5th in EPA per play and 4th in success rate. There are plenty of avenues for Detroit to score in this game, and it all starts on the ground for Dan Campbell’s group. That success running the football should continue against a leaky Giants defense that is dead last in both EPA per rush allowed and in explosive runs allowed. If the Lions are able to jump out to an early lead, that could spell major trouble for a Giants team that isn’t really equipped to play from behind given its current uncertainty at quarterback. I’ll lay the points with the home team in what should be a smash spot for Detroit. 

Giants vs Lions prediction: Detroit Lions -10 (-110) available at time of publishing. Playable at that number.

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Caleb Wilfinger
Game Totals Pick
Over 50.0(-110)

Given the fact that my preferred side in this game is Detroit, that coincides well with the game going over the posted total.  The last time Detroit suffered a loss, it followed that poor effort up with a 44-22 beatdown of the Commanders, and the Lions also put up 52 points at home against the Bears after the previous time they suffered a defeat earlier this season. As previously mentioned, New York is not a team that has the defense to slow down this elite Lions offense, particularly on the ground. Detroit should be able to succeed on early downs and strike for explosive plays throughout this contest. And on the other side, the Giants should be able to tally at least 17 points against this middling Lions defense, regardless of who suits up at quarterback. With that in mind, let’s grab the over while it’s still below the key number of 51.

Giants vs Lions prediction: Over 50 (-110) available at time of publishing. Playable to 50.5.

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Caleb Wilfinger
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Caleb Wilfinger

Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.
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Top Trends
Point Spread

The Lions are 8-2 against the spread in their last 10 games as favorites.

Game Totals

The Lions have scored exactly 31 points in their last 2 games against the Giants.

Money Line

The Giants have lost 11 straight road games.

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