HomeNFLNFL PredictionsNew York Jets vs Buffalo Bills Predictions, Odds & Expert Picks for NFL Week 18 2026

New York Jets vs Buffalo Bills Predictions, Odds & Expert Picks for NFL Week 18 2026 for Sunday, 01/04/26

Updated: 9:06 AM ET Jan 02, 2026

Highmark StadiumCBS

Jets

4:25 PM ETSun Jan 4

Bills

WLLLL	Last 5	WWWWL
3-13	Record	11-5
7-9-0	ATS Record	7-9-0
10-6	O/U Record	8-8

Jets vs Bills Best Bets

Point Spread PickBest Bet

BUF Bills -6.5(-110)

Reasoning

This spread has dropped massively with the news that Josh Allen may miss this matchup, but it feels like a huge overreaction, and it’s worth jumping all over the Bills to beat the woeful Jets by at least a touchdown. Allen’s potential absence would be a blow for Buffalo, but this Jets defense has completely collapsed in recent weeks, giving up 34, 48, 29 and 42 points across its last 4 games. In fact, New York has lost each of those games by at least 23 points, and if Tyler Shough and the Saints can inflict that sort of damage on the Jets, I have full confidence that Mitch Trubisky can do the same at a rowdy Highmark Stadium.

While the Bills are already locked into a Wild Card spot, they can still improve their seeding, and we should still see a spirited effort from Sean McDermott’s team. They had won 4 straight prior to last week’s setback against the Eagles, and Buffalo will no doubt want to gain some momentum ahead of their playoff journey.

As for this Jets team, it’s unbelievable how much they’ve fallen apart in recent weeks. Brady Cook is once again slated to start under center, and while he hasn’t been completely terrible, putting him in a potential snow game in sub-zero temperatures in Buffalo is just asking for trouble. With 10 points or fewer scored in 3 of their last 4 games and the defense set to break all sorts of records by not recording a single interception all season, there’s nothing promising for the Jets here. Even if the Bills do shut down some of their starters for this one, expect them to still pummel New York by at least a touchdown.

Jets vs Bills best bet: Buffalo Bills -6.5 (-110) available at time of publishing. Playable to 9.5.

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Jets vs Bills Pickswise Expert Predictions

Game Totals Pick

Under 37.5(-110)

Reasoning

We have an interesting situation here where the Bills offense could be depleted, yet the Jets defense is giving up lots of points to everyone. Conversely, the Jets offense is in woeful shape right now, and it’s hard to see them generating many scores with Brady Cook back under center in rough conditions. All things considered, I believe a lower-scoring game is more likely here, so it’s worth taking a shot on the under. The Jets have scored 46 total points across their last 4 games (an average of 11.5 per game), and it’s hard to see Cook turning that around against a Bills team that has allowed the fewest passing yards in the NFL. Breece Hall has remained a slight positive for this team and should be leaned on given Buffalo’s struggles against the run, but Sean McDermott will no doubt have that well scouted and look to bottle him up to force Cook to throw it.

New York’s defense has given up huge numbers here, but the Bills could be content with running the clock out if they get out to a solid lead early, especially as they look to avoid any potential injuries ahead of the playoffs. Plus, if Mitch Trubisky is indeed under center, it could take him a few drives to fully get back up to game speed. It’s a tough one to call, but given the snow forecast and differing motivations for this game, the under feels like the right side to be on.

Jets vs Bills pick: Under 37.5 (-110) available at time of publishing. Playable at that number.

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Show Bio

Managing Editor of Pickswise. Born and raised in jolly old London, England, with an undying love for the NFL, NBA, soccer and horse racing. A big-time sports bettor who loves futures markets and backing underdogs. Long-suffering New York Jets fan. For Andrew Wilsher media enquiries, please email contact@pickswise.com.

@aWilsher94

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Parlay Pick

1:00 PM ETSun Jan 4

Sunday's NFL Week 18 parlay

Top Trends

Point Spread

The Bills are 7-9 ATS this season.

Game Totals

The Over/Under is a level 8-8 in Bills games this season.

Money Line

The Jets are 3-13 this season and have lost their last 4.

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Buffalo Bills running back James Cook (4) celebrates with teammates after scoring a touchdown.

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