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San Francisco 49ers

49ers vs Eagles Predictions, Odds & Expert Picks for NFL Wild Card Round for Sunday, 01/11/26

Lincoln Financial FieldFOX
49ers
12-5
49ers
Sun Jan 11
Eagles
11-6
Eagles
Philadelphia Eagles
Google News

49ers vs Eagles Guest Expert Predictions

Point Spread PickBest Bet
SF 49ers +4.5(-110)

The San Francisco 49ers (12-5) withstood a bunch of injuries to key players this season, including QB Brock Purdy missing 8 games. The Niners had an opportunity at the top seed in the NFC before falling at home to the Seahawks last Saturday, 13-3. San Francisco fell to the 6th seed, getting set to face the defending champion Philadelphia Eagles (11-6). There were plenty of ups and downs for the Eagles, including 3 winning streaks of 3 games and a losing skid of 3 games, but they managed to grab the NFC East title for a 2nd straight season.

Philadelphia and San Francisco each finished with 10-7 ATS marks, while the Niners won 7 of 9 games away from Levi’s Stadium. Head coach Kyle Shanahan’s squad beat the Seahawks and Rams on the road in the first 5 weeks, but the other 5 away victories came against teams with losing records. The 49ers posted a 2-4 ATS ledger in the underdog role, which included an overtime triumph over the Rams as a 6.5-point dog in Week 5. The Eagles compiled a 4-4 ATS record at Lincoln Financial Field, including outright defeats to the Broncos and Bears. Philadelphia ranked 24th in yards per game (311.2), the 3rd-fewest for any playoff team after ranking 8th in this category during its Super Bowl run last season.

These teams last met in December 2023 when the Niners roughed up the Eagles at the Linc 42-19 as 3.5-point road favorites. Purdy threw 4 TD passes, while now-departed WR Deebo Samuel scored 3 times. In their last playoff matchup in the 2022 NFC Championship, the Eagles shredded the 49ers 31-7, but Purdy was hurt early and San Francisco was forced to run the ball basically the entire game. The Niners are 6-3 in the playoffs under Shanahan since 2021 and have not been bounced in their first game. Let’s back the 49ers with the points against the defending champs.

49ers vs Eagles best bet: San Francisco 49ers +4.5 (-110) available at time of publishing. Playable to 3.5.

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Kevin Rogers
Game Totals Pick
Under 44.5(-110)

The Niners went 10-7 to the over this season, while the Eagles posted a 10-7 under mark for the second consecutive year. Six of San Francisco’s 9 road games cashed the over, as the 49ers topped the 34-point mark in 3 of the final 4 away contests. In the 2 road games against playoff teams, San Francisco allowed a total of 36 points to Seattle and Los Angeles. Philadelphia went 5-3 to the under at home, while allowing 21 or less 5 times. Down the stretch, the Eagles scored fewer than 21 points in 7 of 9 games.

The Eagles ranked 8th in the league in passing yards allowed per game (189.8), facing a 49ers offense that placed 5th in passing yards even though starting QB Brock Purdy played in only 9 games. Purdy averaged 240.7 passing yards in his 9 appearances, while backup Mac Jones put up 268.8 passing yards in his 8 starts. Philadelphia QB Jalen Hurts threw for more yards this season (3,224) than in last season’s Super Bowl run (2,903), but averaged a shade over 200 yards passing.

This total sits at 44.5 as Philadelphia finished with a 7-2 under ledger in the final 9 games. One of those overs came in the season finale against Washington on a 38.5 total; the Commanders scored a pair of 4th-quarter TDs in a 24-17 win. The Niners compiled a 3-1 under mark on the road with a total of 45 or less. Each of the last 3 playoff openers for Philadelphia have finished under the total with combined totals of 45, 41, and 32. Let’s look at the under here in a game with both teams staying in the low-20’s.

49ers vs Eagles prediction: Under 44.5 (-110) available at time of publishing. Playable to 44.

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Kevin Rogers
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Kevin Rogers

Kevin covers the NFL for Pickswise from sunny south Florida. He has been handicapping the NFL professionally since 2007, as well the NBA, MLB, NHL, college football, and college basketball. He looks forward to a profitable season at Pickswise.
@RogersPicks
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