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San Francisco 49ers

49ers vs Eagles Predictions, Odds & Expert Picks for NFL Wild Card Round for Today, 01/11/26

Lincoln Financial FieldFOX
49ers
12-5
49ers
Today
Eagles
11-6
Eagles
Philadelphia Eagles

49ers vs Eagles Best Bets

Point Spread PickBest Bet
SF 49ers +4.5(-110)

The San Francisco 49ers (12-5) withstood a bunch of injuries to key players this season, including QB Brock Purdy missing 8 games. The Niners had an opportunity at the top seed in the NFC before falling at home to the Seahawks last Saturday, 13-3. San Francisco fell to the 6th seed, getting set to face the defending champion Philadelphia Eagles (11-6). There were plenty of ups and downs for the Eagles, including 3 winning streaks of 3 games and a losing skid of 3 games, but they managed to grab the NFC East title for a 2nd straight season.

Philadelphia and San Francisco each finished with 10-7 ATS marks, while the Niners won 7 of 9 games away from Levi’s Stadium. Head coach Kyle Shanahan’s squad beat the Seahawks and Rams on the road in the first 5 weeks, but the other 5 away victories came against teams with losing records. The 49ers posted a 2-4 ATS ledger in the underdog role, which included an overtime triumph over the Rams as a 6.5-point dog in Week 5. The Eagles compiled a 4-4 ATS record at Lincoln Financial Field, including outright defeats to the Broncos and Bears. Philadelphia ranked 24th in yards per game (311.2), the 3rd-fewest for any playoff team after ranking 8th in this category during its Super Bowl run last season.

These teams last met in December 2023 when the Niners roughed up the Eagles at the Linc 42-19 as 3.5-point road favorites. Purdy threw 4 TD passes, while now-departed WR Deebo Samuel scored 3 times. In their last playoff matchup in the 2022 NFC Championship, the Eagles shredded the 49ers 31-7, but Purdy was hurt early and San Francisco was forced to run the ball basically the entire game. The Niners are 6-3 in the playoffs under Shanahan since 2021 and have not been bounced in their first game. Let’s back the 49ers with the points against the defending champs.

49ers vs Eagles best bet: San Francisco 49ers +4.5 (-110) available at time of publishing. Playable to 3.5.

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Kevin Rogers

49ers vs Eagles Pickswise Expert Predictions

Game Totals Pick
Under 44.5(-110)

The Niners went 10-7 to the over this season, while the Eagles posted a 10-7 under mark for the second consecutive year. Six of San Francisco’s 9 road games cashed the over, as the 49ers topped the 34-point mark in 3 of the final 4 away contests. In the 2 road games against playoff teams, San Francisco allowed a total of 36 points to Seattle and Los Angeles. Philadelphia went 5-3 to the under at home, while allowing 21 or less 5 times. Down the stretch, the Eagles scored fewer than 21 points in 7 of 9 games.

The Eagles ranked 8th in the league in passing yards allowed per game (189.8), facing a 49ers offense that placed 5th in passing yards even though starting QB Brock Purdy played in only 9 games. Purdy averaged 240.7 passing yards in his 9 appearances, while backup Mac Jones put up 268.8 passing yards in his 8 starts. Philadelphia QB Jalen Hurts threw for more yards this season (3,224) than in last season’s Super Bowl run (2,903), but averaged a shade over 200 yards passing.

This total sits at 44.5 as Philadelphia finished with a 7-2 under ledger in the final 9 games. One of those overs came in the season finale against Washington on a 38.5 total; the Commanders scored a pair of 4th-quarter TDs in a 24-17 win. The Niners compiled a 3-1 under mark on the road with a total of 45 or less. Each of the last 3 playoff openers for Philadelphia have finished under the total with combined totals of 45, 41, and 32. Let’s look at the under here in a game with both teams staying in the low-20’s.

49ers vs Eagles prediction: Under 44.5 (-110) available at time of publishing. Playable to 44.

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Kevin Rogers
Player Receptions Pick
S. Barkley (PHI) - Under 2.5 recs(-122)

Whenever you take an under for a guy this talented, you put yourself in a position to look dumb. With that being said, I love this bet. Saquon is under this mark in 5 straight games and 4 of those games he failed to reel in even one catch. Averaging 0.4 receptions is wild when his line is ballooned up to needing 3 total.

The Eagles are 5.5-point favorites, which implies that they should play with a lead, and when Saquon is out there, he should be utilized as a runner. We have seen Will Shipley come in on 3rd downs on occasion in clear passing situations and I think he is more likely to see pass work in this one. The 49ers allow the 2nd0most receptions to RBs, which is likely why this line is so high, but that doesn’t guarantee the work is going to Saquon. Both the Eagles and 49ers should run the heck out of the ball, which will likely lead to fewer possessions and less of a chance that Barkley sees 3+ receptions. It’s ugly, but it’s my favorite play for this game. Let’s roll!

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Josh Gayle (ThatGuyBets)
Players to record 10+ rush yards in every quarter Pick
S. Barkley & C. McCaffrey to both record 10+ rush yards in every quarter(+1900)

This is a DK special under “Game Specials” and it feels fun. Whenever you make a play at +1900 odds, you want to play this very light and treat it like a lotto ticket. Both of these runners are established studs and this game projects to be close. The recipe for this hitting is both teams need to be close in the 4th quarter so they each feel like running is viable. These are 2 of the league’s best and their offenses could surely lean on them both. This is worth a sprinkle given how windy this game is forecast to be, too.

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Josh Gayle (ThatGuyBets)
Photo of Kevin Rogers

Kevin Rogers

Kevin covers the NFL for Pickswise from sunny south Florida. He has been handicapping the NFL professionally since 2007, as well the NBA, MLB, NHL, college football, and college basketball. He looks forward to a profitable season at Pickswise.
@RogersPicks
Read more about Kevin Rogers

Star Expert Prop Picks

Player Receptions Pick
S. Barkley (PHI) - Under 2.5 recs(-122)

Whenever you take an under for a guy this talented, you put yourself in a position to look dumb. With that being said, I love this bet. Saquon is under this mark in 5 straight games and 4 of those games he failed to reel in even one catch. Averaging 0.4 receptions is wild when his line is ballooned up to needing 3 total.

The Eagles are 5.5-point favorites, which implies that they should play with a lead, and when Saquon is out there, he should be utilized as a runner. We have seen Will Shipley come in on 3rd downs on occasion in clear passing situations and I think he is more likely to see pass work in this one. The 49ers allow the 2nd0most receptions to RBs, which is likely why this line is so high, but that doesn’t guarantee the work is going to Saquon. Both the Eagles and 49ers should run the heck out of the ball, which will likely lead to fewer possessions and less of a chance that Barkley sees 3+ receptions. It’s ugly, but it’s my favorite play for this game. Let’s roll!

BET +2.5 NOW WITH
Josh Gayle (ThatGuyBets)
Players to record 10+ rush yards in every quarter Pick
S. Barkley & C. McCaffrey to both record 10+ rush yards in every quarter(+1900)

This is a DK special under “Game Specials” and it feels fun. Whenever you make a play at +1900 odds, you want to play this very light and treat it like a lotto ticket. Both of these runners are established studs and this game projects to be close. The recipe for this hitting is both teams need to be close in the 4th quarter so they each feel like running is viable. These are 2 of the league’s best and their offenses could surely lean on them both. This is worth a sprinkle given how windy this game is forecast to be, too.

BET +9.5 NOW WITH
Josh Gayle (ThatGuyBets)

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Money Line

The 49ers won 6 of their last 7 games in the regular season.

Game Totals

10 of Philadelphia's 17 regular-season games went under the expected points total.

Point Spread

The 49ers went 7-2 against the spread as the road team this season.

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