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Hello Millions
San Francisco 49ers

49ers vs Seahawks Predictions, Odds & Expert Picks for NFL Divisional Round for Today, 01/17/26

Lumen FieldFOX
49ers
13-5
49ers
Today
Seahawks
14-3
Seahawks
Seattle Seahawks

49ers vs Seahawks Pickswise Expert Predictions

Point Spread Pick
SEA Seahawks -7.5(-105)

If you watched last week‘s game between the 49ers and the Eagles, it wasn’t completely surprising to see the result. Since Brock Purdy has returned as the 49ers’ starting quarterback, their offense has been humming, right up there with the best passing operations in the NFL. Despite throwing 2 interceptions, Purdy was ice cold when it mattered most, going 6-11 on third downs and engineering 13 fourth-quarter points against one of the NFL’s best defenses. Perhaps most impressive about San Francisco’s production was that they only possessed the ball for 24 minutes. 

The Niners defense played well, but some of that is more on Philadelphia’s lackluster offense. The Eagles’ offensive operation has been pedestrian for most of the season, so it wasn’t surprising to see them stumbling through the second half, earning just 6 points and 104 yards in the final 2 quarters. Credit should be given to Robert Saleh and his roster, but we’re also not sure if it’s sustainable. That’s particularly true this weekend.

The Seahawks enter the divisional round off extended rest, and they will host their first playoff game Saturday night. The dominance of their defense has been well documented, completely obliterating San Francisco in their last matchup in Week 18 (they held Brock Purdy and company to just 3 points and 173 yards). Offensively, they left plenty on the field, garnering just 13 points themselves. Most impressively, they ran for 180 yards on 4.6 yards per carry, and completely controlled time of possession because of it (37:48 to 22:12). Their passing attack wasn’t that explosive, but Sam Darnold was efficient (20-26, 198 yards) and the game never felt within reach for the visiting Niners. 

While the rematch might not look the exact same, we are expecting a similar result. San Francisco’s impressive victory last Sunday came at the cost of George Kittle, their all-pro tight end who’s as crucial in blocking as he is in the pass catcher. He tore his Achilles and will be out for the remainder of the season, yet another big loss to a roster that’s been severely beaten up this year. Add to the fact that San Francisco will only have 6 days to prepare for battle after a very physical matchup in the wildcard round and it’s hard not to imagine a Seattle blowout.

49ers vs Seahawks prediction: Seattle Seahawks -7.5 (-105) available at time of publishing. Playable to 8.

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Chris R. Farley
Game Totals Pick
Under 45.5(-110)

The late game on Saturday presents another dead total, resting right under key numbers 46 and 47. In general, this means markets and its constituent bettors think there’s a reasonable chance for a higher-scoring contest, but not a great enough chance that it should come close to 50. In the case of this big NFC matchup, there is certainly reason to believe it will get nowhere near those numbers.

Seattle’s defense had a serious edge in their last battle, which was only 2 weeks ago. Swarming and suffocating throughout the contest, the Niners only made it into the red-zone on one occasion, failing to score a touchdown. Brock Purdy, who has sneaky elusiveness and savvy in the pocket, was sacked 3 times, hit another three times and limited to a 22.8 QBR. He also threw an interception, which has become a trend in 2025 (12 interceptions in 10 games this season, which matches his total in 15 starts in 2024). The Seahawks also held the 49ers to just 53 total rushing yards, a truly shocking mark considering Kyle Shanahan’s emphasis on the run game. 

This season the 49ers are 30th in yards per rush (3.7), so we doubt the Seahawks will have any issues limiting them once again. That means the onus of the Niners’ offense will rest solely on Purdy’s shoulders. The former Iowa State QB has earned some trust, but this situation is different. No George Kittle means a major piece of their offense is missing. Add a raucous Seattle crowd and the fact that Purdy is facing the 2nd-best defense in the NFL (according to advanced EPA metrics), and we don’t feel great about his chances. In short, based on everything we’ve seen from both programs this season, it would take an exceedingly masterful game-plan and an all-world performance by San Francisco’s role players to reach 20-points or better.

Two weeks ago the San Francisco defense made another valiant effort to stymie Seattle’s production. Considering their injuries and many shortcomings throughout this season (they’re 24th in total defensive EPA), we don’t exactly have faith that they can keep their current overperformance going. What we do have faith in is that Robert Saleh is an excellent defensive coach who gets the most out of his players, regardless of their history or prowess. Considering the many other factors that support a low-scoring affair, that should be plenty to keep this total closer to 40 than 45.

49ers vs Seahawks pick: Under 45.5 (-110) available at time of publishing. Playable to 45.

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Chris R. Farley
Photo of Chris Farley

Chris Farley

Chris is a writer for Pickswise who’s been handicapping the NFL since 2011. He began his public betting career as a betting writer, and has since become a contributing analyst for various betting sites and shows. He was a 5th place winner ($114k) in the 2021 NFL Circa Millions contest, and he owns his own sports betting podcast, Laying the Points. Chris approaches handicapping using psychosocial principles and nuanced market analysis. The NFL and NBA are his favorite and most profitable sports.
@FarleyBets
Read more about Chris Farley

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Money Line

The Seahawks have won 11 of their last 12 games.

Point Spread

The Seahawks were 12-5 against the spread in the regular season, while the 49ers went 10-6-1.

Game Totals

The Seahawks have conceded 16 or fewer points in 5 of their last 6 games.

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