Seattle Seahawks vs Jacksonville Jaguars Prediction, Odds and Picks for Sunday, 10/12/25

Two teams that have been rolling recently will meet here, as the Jacksonville Jaguars host the Seattle Seahawks in Week 6. Jacksonville has been one of the league’s most pleasant surprises at 4-1, while the Sam Darnold era in Seattle couldn’t have started much better — as they enter this one having won 3 of 4 with the only loss coming in a game where they still scored 35 points. I’m a big Liam Coen fan, but I don’t think they’ve played as well as 4-1 might indicate, and I’m fading the Jags here.

Yes they picked up a thrilling 3-point comeback win over the Chiefs last week, but that took a herculean effort to squeak out, and the Seahawks are playing objectively better than the Chiefs right now. Jacksonville’s other 3 wins don’t look great when you look closely. First, they beat a terrible Panthers team, then a Texans team that was at rock bottom in an ugly 17-10 game, and then the 49ers in a game in which Brock Purdy returned too early from injury and played terribly. Now is the time to sell high on the Jags coming off their biggest win in quite some time because it’s not like Trevor Lawrence is actually playing well.

He’s averaging just 6.3 yards per attempt, by far the lowest mark since his rookie season, and has 6 touchdowns to go with 5 interceptions. It’s the complete opposite for Darnold, who has quietly been one of the most efficient quarterbacks in the league, averaging 9.3 yards per attempt. The Seahawks’ 2 losses this season came to good 49ers and Bucs teams, and they both were by 4 points or fewer. Jacksonville is also on a short week here off the draining victory as their win over Kansas City was Monday night, and everything is pointing toward Seattle for me here.

Seahawks vs Jaguars best bet: Seattle Seahawks +1 (-115) available at time of publishing. Playable to PK.

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I think this one has shootout potential. The Seahawks seem to be playing in shootouts every week, and they’ve scored at least 31 points in 3 out of 4 games. Last week they gave up 38 points at home to a Bucs team that was without both Mike Evans and Bucky Irving. The Jaguars are no strangers to high scoring affairs this season either, as their last game against Kansas City ended 31-28, while Jacksonville has quietly put up 26+ points in 4 of 5 games to start the year.

Sam Darnold is playing out of his mind, and just picked apart Tampa Bay for 10 yards per attempt, 4 touchdowns and only 6 incompletions last week. If you take out his Week 1 performance, in which he was clearly getting his legs under him and feeling out a brand new system, his numbers are astronomical. Jaxon Smith-Njigba has officially established himself as one of the league’s true premier receivers, and he’s led the team in receiving in all 5 games. I’m expecting lots of points here.

Seahawks vs Jaguars prediction: Over 47.5 (-110) available at time of publishing. Playable to 48.

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