HomeNFLNFL PredictionsSeattle Seahawks vs San Francisco 49ers Predictions, Odds & Expert Picks for NFL Week 18 2025

Seattle Seahawks vs San Francisco 49ers Predictions, Odds & Expert Picks for NFL Week 18 2025 for Saturday, 01/03/26

Updated: 5:42 AM ET Dec 31, 2025

Levi's StadiumABC, ESPN

Seahawks

8:00 PM ETSat Jan 3

49ers

WWWWW	Last 5	WWWWW
13-3	Record	12-4
11-5-0	ATS Record	11-5-0
9-7	O/U Record	10-6

Seahawks vs 49ers Pickswise Expert Predictions

Point Spread Pick

SEA Seahawks -1.5(-110)

Reasoning

NFL schedule makers have done it again, as 2 NFC titans will clash for not only the claim of NFC West champions but the #1 seed in the conference. Both rosters are rounding into their best form to end the season. As if this game wasn’t hard enough to predict, the home team has been great in front of their fans, 5-2 straight up, while the Seahawks have been road warriors all season (7-1). In a span of 2 days, Seattle has moved from a slight underdog to a slight favorite. We wouldn’t be surprised at all if that switched again before kickoff.

Look at either program, and you will see nothing but wins throughout December and beyond. After a 2-point loss to the Rams in Week 11, Seattle has won 6 straight games. They had a memorable comeback win against the Rams in the rematch and proceeded to display impressive margin victories over the Vikings, Falcons and Panthers in recent weeks. Just 2 years in, coach Mike Macdonald has taken full advantage of his defensive talent, the side of the ball where he has the most expertise, and newcomer Sam Darnold proved his worth immediately. He’s looking to achieve his 2nd straight 14-3 season with 2 different teams. Even better, the Seahawks are one of the healthiest teams in the NFL, sprinting full speed towards the postseason with very few holes on their roster. Their offense has sputtered here and there down the stretch (now 16th in total offensive EPA), but they have more than enough firepower to get the job done when they need to.

Like the Seahawks, the 49ers’ last loss was against the Rams in Week 10, but since then, they’ve been relatively flawless. An easier schedule has certainly helped, but with Brock Purdy back in the fold, San Francisco has gone 6-0, winning by an average margin of +14.3 points per game. That doesn’t happen by accident. Even with virtually no defense last Sunday, the 49ers scored at will on the Bears at home, putting up 42 points and going 5-5 in the red zone. Their Achilles heel will continue to be their defense, which was heavily injured midway through the season, but their offense is firing on all cylinders (now 6th in total EPA).

This is a very tough pick and would probably work better as a teaser (San Francisco from +1.5 to +7.5 feels ideal), but since we must pick a side, we’ll go with the visitors, who are a more complete operation right now.

Seahawks vs 49ers prediction: Seahawks -1.5 (-110) available at time of publishing. Playable at that number.

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Game Totals Pick

Under 49.5(-110)

Reasoning

There is no doubt that the Seahawks are one of the most complete rosters in football, although their offense has regressed a little down the stretch. Underwhelming opponents like Tennessee and the banged-up Colts have been less demanding matchups, which may have something to do with the underperformance. On Saturday, the situation will be entirely different, and they’ll be facing a San Francisco defense that’s been allowing plenty of production from their enemies lately.

The 49ers’ home win against the Bears, who were a fellow threat for the #1 seed, was impressive in Week 17, but they had no answer for the visitors’ offense. The Bears put up 440 yards on the Niners’ resistance on Sunday night, par for the course for Robert Saleh’s group this season. Early on, they weren’t great, but since they lost Fred Warner in Week 6, the difference is glaring. In the preceding games, the San Francisco defense allowed 475 yards to the Texans, 488 to the Cardinals, 306 to the lowly Titans and 312 to the Colts with 44-year-old Phillip Rivers at quarterback. In short, the Seahawks will have their chances on Saturday night.

Where this total will finish will likely depend on the other side of the ball. The Seattle defense is ranked 2nd in total EPA behind only the Texans, who are a historic unit this season. In Week 1, before the Seahawks’ defense had a chance to round into form, the 49ers got the better of the 2 programs, winning 17-13 in a close battle. San Francisco still gained 384 yards and 24 first downs on that day, but we have reason to believe they won’t be quite as potent in Week 18. Seattle’s defense is for real, ranked 1st in opponent yards per pass and rush, and no team allows fewer explosive plays. Just like he did during his tenure in Baltimore, Macdonald has instilled discipline and moxie in his roster. We like them to show up fiery for this nighttime matchup, which should slow down scoring right from the opening kickoff.

As much as we’d like to see both offenses light up the scoreboard, we’re fading the market in this one. Saleh and Macdonald know how to coach up their guys for playoff football, which is the exact feel this game will have.

Seahawks vs 49ers best bet: Under 49.5 (-110) available at time of publishing. Playable to 48.5.

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Chris Farley

Show Bio

Chris is a writer for Pickswise who’s been handicapping the NFL since 2011. He began his public betting career as a betting writer, and has since become a contributing analyst for various betting sites and shows. He was a 5th place winner ($114k) in the 2021 NFL Circa Millions contest, and he owns his own sports betting podcast, Laying the Points. Chris approaches handicapping using psychosocial principles and nuanced market analysis. The NFL and NBA are his favorite and most profitable sports.

@FarleyBets

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4:30 PM ETSat Jan 3

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Point Spread

The 49ers have covered the spread in 4 of their last 5 games against teams with winning records.

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