Seattle Seahawks vs Tennessee Titans Prediction, Odds and Picks for Sunday, 11/23/25

This Week 12 matchup between the Seahawks and Titans is a pretty significant mismatch on paper, and it’s hard to see this imbalance not translating to the field. For starters, the Titans have plenty of issues, and now Tennessee is banged up on both sides of the ball. We likely won’t see Calvin Ridley this week, and the same can be said of Jeffrey Simmons, who is probably the most important player on the Tennessee defense. Now, an already struggling team has to take on a Seahawks side that is coming off an extremely frustrating loss to the Rams a week ago, in which Seattle outgained Los Angeles by nearly 200 yards and finished with nearly double the amount of first downs, only to still fall short thanks to 4 awful interceptions from Sam Darnold. Mike Macdonald’s team should be motivated to put a beating on one of the worst teams in football, and that’s exactly what I think we’ll see here on Sunday.

Coming into last week’s game, the Seahawks boasted what was arguably the best passing offense in football, and we can expect them to get back on track against a Titans defense that is missing some pieces up front and in the secondary. But the real advantage that the visitors hold in this game comes on the other side of the ball, where Seattle will pit its excellent defense (5th in EPA per play and success rate allowed, 2nd in EPA per rush) against a Titans offense that has been among the worst units in football all season long with rookie quarterback Cam Ward at the helm. We can expect Seattle to pin its ears back and get after the quarterback, and I’d be surprised if Ward was able to beat this secondary over the top. Lay the points with the Seahawks in this one.

Seahawks vs Titans prediction: Seahawks -13 available at time of publishing. Playable to -13.5

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