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Seattle Seahawks

Seattle Seahawks vs Tennessee Titans Predictions, Odds & Expert Picks for NFL Week 12 2025 for Today, 11/23/25

Nissan StadiumFOX
Seahawks
Seahawks
Today
Titans
Titans
WWWWL
Last 5
LLLLL
7-3Record1-9
8-2-0ATS Record4-6-0
6-4O/U Record6-4
Tennessee Titans

Seahawks vs Titans Pickswise Expert Predictions

Point Spread Pick
SEA Seahawks -13.0(-110)

This Week 12 matchup between the Seahawks and Titans is a pretty significant mismatch on paper, and it’s hard to see this imbalance not translating to the field. For starters, the Titans have plenty of issues, and now Tennessee is banged up on both sides of the ball. We won’t see Calvin Ridley this week, and the Titans may also be without Jeffrey Simmons – who is probably the most important player on the Tennessee defense. Now, an already struggling team has to take on a Seahawks side that is coming off an extremely frustrating loss to the Rams a week ago, in which Seattle outgained Los Angeles by nearly 200 yards and finished with nearly double the amount of first downs, only to still fall short thanks to 4 awful interceptions from Sam Darnold. Mike Macdonald’s team should be motivated to put a beating on one of the worst teams in football, and that’s exactly what I think we’ll see here on Sunday.

Coming into last week’s game, the Seahawks boasted what was arguably the best passing offense in football, and we can expect them to get back on track against a Titans defense that is missing some pieces up front and in the secondary. But the real advantage that the visitors hold in this game comes on the other side of the ball, where Seattle will pit its excellent defense (5th in EPA per play and success rate allowed, 2nd in EPA per rush) against a Titans offense that has been among the worst units in football all season long with rookie quarterback Cam Ward at the helm. We can expect Seattle to pin its ears back and get after the quarterback, and I’d be surprised if Ward was able to beat this secondary over the top. Lay the points with the Seahawks in this one.

Seahawks vs Titans prediction: Seattle Seahawks -13 (-110) available at time of publishing. Playable to -13.5

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Caleb Wilfinger
Game Totals Pick
Under 40.5(-110)

There’s a lot to like about the under in this game, especially considering that I have a hard time seeing Tennessee scoring much on this elite Seattle defense. The Seahawks were put in a bad position time and again in their loss to the Rams a week ago, but it was the defense that allowed Seattle to have a real shot at winning that game in the first place. In fact, the Seahawks defense repeatedly stopped Los Angeles after the Rams were handed good field position multiple times in the second half thanks to the interceptions from Darnold. This is a much easier matchup for Mike Macdonald’s unit, and it wouldn’t shock me if Tennessee finished with 10 points or fewer in a spot where the much better team also has a massive motivation edge.

Titans vs Seahawks pick: Under 40.5 (-110) available at time of publishing. Playable to 40.

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Caleb Wilfinger
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Caleb Wilfinger

Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.
Read more about Caleb Wilfinger

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Point Spread

The Seahawks have covered the spread in their last 3 games as road favorites.

Game Totals

The Over is 12-8 in the Seahawks' and the Titans' last 10 games combined.

Money Line

The Seahawks have won 18 of their last 20 road matchups against teams with worse records.

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