Tampa Bay Buccaneers

Tampa Bay Buccaneers vs Carolina Panthers Prediction, Odds and Picks for Today, 12/21/25

Bank of America StadiumFOX
Buccaneers
Buccaneers
Today
Panthers
Panthers
LLWLL
Last 5
LWLWL
7-7Record7-7
5-9-0ATS Record8-6-0
8-6O/U Record7-7
Carolina Panthers

Buccaneers vs Panthers Best Bets

Point Spread PickBest Bet
TB Buccaneers -3.0(-108)

Tampa Bay and Carolina enter Sunday’s critical NFC South matchup tied atop the division at 7-7. The Buccaneers have slumped down the stretch, dropping 5 of their last 6 games with the lone victory coming by 3 against the Cardinals in Week 13. Tampa Bay visits Bank of America Stadium against a Carolina squad that lost on a field goal in the final seconds of last Sunday’s 20-17 defeat at New Orleans. Carolina led New Orleans 17-7 late in the third quarter before the Saints scored the final 13 points of the game.

The Panthers are 5-1 off a loss this season. In the underdog role, Carolina has posted a solid 8-3 ATS mark, including a 4-1 ATS record at home. In their last home game, the Panthers stunned the Rams as 10.5-point underdogs 31-28 in their highest-scoring game of the season. Carolina has scored 61 points in its last 2 games off a loss, but has also allowed 55 points in those victories.

Tampa Bay needs to get on track fast, as the Buccaneers control their destiny with 2 meetings against the Panthers over the final 3 games. The Bucs shouldn’t be in this position, as they lost to 2 teams at home that are not headed to the playoffs – the Saints and Falcons. In fact, the Bucs are 0-6 ATS in the last 6 games, but have not been listed as a road favorite in this stretch. Tampa Bay is 2-0 SU/ATS in 2 opportunities when laying points away from Raymond James Stadium, winning at Atlanta and New Orleans. In the past 10 matchups, the Buccaneers are 9-1 against the Panthers, and QB Baker Mayfield has not lost to Carolina since taking over in 2023. The trends point towards Carolina, but this looks like the get-right game for Tampa Bay to save its season, so we’ll lay the points with the Bucs.

Buccaneers vs Panthers prediction: Tampa Bay Bucs -3 (-108) available at time of publishing. Playable at that number.

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Buccaneers vs Panthers Pickswise Expert Predictions

Game Totals Pick
Over 45.5(-110)

Neither of these division rivals own overwhelming numbers in the totals department. The Bucs are 8-6 to the over, while the Panthers are 7-7 in that regard. Carolina has been inconsistent in this category due its erratic play this season, alternating overs and unders in the last 5 games, and the Panthers are coming off an under in last Sunday’s 20-17 walk-off loss at New Orleans on a 41.5 total. Tampa Bay is off consecutive overs in the past 2 home defeats to New Orleans and Atlanta, while giving up at least 27 points at home for the 4th time last Thursday against the Falcons.

The last 2 road defensive outings for the Buccaneers have been ugly, yielding 34 points to the Rams and 44 points to the Bills in a pair of losses. In both games as a road favorite, Tampa Bay finished under the total in the Week 1 comeback victory at Atlanta and the 23-3 rout of New Orleans in Week 8. Tampa Bay and Carolina see each other twice in the final 3 weeks of the season with the division crown on the line, as both matchups in 2024 sailed over the total. The Bucs rank 25th in the NFL in yards allowed per game (348.2) and surrender 25.3 ppg.

Carolina’s roller-coaster season is defined by this number: the Panthers average 18.9 ppg, although they have scored at least 30 points in 4 games. They have also been held to 13 or fewer points 4 times, so you wonder which Carolina offense shows up on Sunday in this critical showdown. We’ll buy into the trend that the Panthers will score points here against this struggling Tampa Bay defense, while the Bucs can put up points, as well, in what should be an exciting game with first place on the line in the NFC South.

Buccaneers vs Panthers: Over 45.5 (-110) available at time of publishing. Playable to 46.5.

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Kevin covers the NFL for Pickswise from sunny south Florida. He has been handicapping the NFL professionally since 2007, as well the NBA, MLB, NHL, college football, and college basketball. He looks forward to a profitable season at Pickswise.
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Top Trends
Money Line

The Panthers have a 4-2 record at home this season

Game Totals

The Over is 12-8 in the Panthers' and the Bucs' last 10 games combined

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