Tennessee Titans vs Indianapolis Colts predictions for Today, 10/26/25

One of the NFL’s biggest disappointments will take on one of its most pleasant surprises as the Tennessee Titans visit the Indianapolis Colts. Things have gone so poorly for Tennessee that it has already fired the coach less than 2 months into the season. So much for a honeymoon for Cam Ward. The first overall pick in this past draft hasn’t done much to inspire confidence, and not all of his struggles can be blamed on coaching or circumstance. Take last week, for example, when the ball slipped out of his hands as he cocked it backward in the closing seconds to end the game with a lost fumble.

Ward has missed plenty of throws and doesn’t look ready for primetime. While I normally don’t like laying it with spreads this large, if there’s one team who has shown an ability to run up the score this season, it’s the Colts. Indy’s offense has been a revelation, and head coach Shane Steichen has QB Daniel Jones playing like one of the best quarterbacks in the league to go along with RB Jonathan Taylor spearheading one of the best ground attacks in the league. They have steamrolled opponents on offense, scoring at least 29 points in 6 of their 7 games. Imagine saying that before the season.

One of those steamrolled opponents was this same Titans team when these squads met back in Week 3. Indy dropped 41 in that one while cruising to a 21-point victory — and that game was played in Tennessee. It was also played when the Titans still had Calvin Ridley, who is now sidelined with a hamstring injury. All 6 of Tennessee’s losses this season have come by 8 points or more, so it’s not like this club been playing many nailbiters. I don’t expect this one to be particularly competitive.

Tennessee Titans vs Indianapolis Colts prediction: Colts -14.5 (-110) available at time of publishing. Playable at that number.

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The over also makes a lot of sense. The Colts have featured arguably the best offense in the league this season and they dropped 41 points when these teams played each other a few weeks ago. To make matters worse for the Titans’ defensive outlook, they are going to be without defensive tackle Jeffery Simmons — the best player on the entire team. Indy’s defense has been a bit shaky; it has given up 24 and 27 points the last 2 weeks to the Chargers and Cardinals, respectively. Even Tennessee should be able to have just a little bit of success this weekend.

It’s a very low bar, but Cam Ward actually had one of his “best” games of the year when these teams first played and was able to move the ball somewhat well for most of the day. This contest will be played in a dome between 2 middling defenses and the Colts have scored 29+ points in all but one game this season, so this one feels like it has sneaky shootout potential to me.

Tennessee Titans vs Indianapolis Colts prediction: Over 47.5 (-110) available at time of publishing. Playable to 48.

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