NFL Best Bets

Get our experts’ best NFL bets this week and every week of the 2025/26 season. Our experts analyze their NFL picks and predictions across a whole host of markets to give you their best NFL Bets today.

Read More
Filter Picks
Filter Picks
Bet Type
Experts
1:00 PM ET
Sun Dec 21
Tampa Bay Buccaneers
Carolina Panthers
Buccaneers
Panthers
Point Spread PickBest Bet
TB Buccaneers -3.0(-108)

Tampa Bay and Carolina enter Sunday’s critical NFC South matchup tied atop the division at 7-7. The Buccaneers have slumped down the stretch, dropping 5 of their last 6 games with the lone victory coming by 3 against the Cardinals in Week 13. Tampa Bay visits Bank of America Stadium against a Carolina squad that lost on a field goal in the final seconds of last Sunday’s 20-17 defeat at New Orleans. Carolina led New Orleans 17-7 late in the third quarter before the Saints scored the final 13 points of the game.

The Panthers are 5-1 off a loss this season. In the underdog role, Carolina has posted a solid 8-3 ATS mark, including a 4-1 ATS record at home. In their last home game, the Panthers stunned the Rams as 10.5-point underdogs 31-28 in their highest-scoring game of the season. Carolina has scored 61 points in its last 2 games off a loss, but has also allowed 55 points in those victories.

Tampa Bay needs to get on track fast, as the Buccaneers control their destiny with 2 meetings against the Panthers over the final 3 games. The Bucs shouldn’t be in this position, as they lost to 2 teams at home that are not headed to the playoffs – the Saints and Falcons. In fact, the Bucs are 0-6 ATS in the last 6 games, but have not been listed as a road favorite in this stretch. Tampa Bay is 2-0 SU/ATS in 2 opportunities when laying points away from Raymond James Stadium, winning at Atlanta and New Orleans. In the past 10 matchups, the Buccaneers are 9-1 against the Panthers, and QB Baker Mayfield has not lost to Carolina since taking over in 2023. The trends point towards Carolina, but this looks like the get-right game for Tampa Bay to save its season, so we’ll lay the points with the Bucs.

Buccaneers vs Panthers prediction: Tampa Bay Bucs -3 (-108) available at time of publishing. Playable at that number.

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Buccaneers vs Panthers predictions.

1:00 PM ET
Sun Dec 21
Buffalo Bills
Cleveland Browns
Bills
Browns
Point Spread PickBest Bet
BUF Bills -10(-125)

The Buffalo Bills will try to build on a massive win over their AFC East rival Patriots when they visit the Cleveland Browns in Week 16 of the NFL season on Sunday afternoon. My Bills vs. Browns pick is for the visitors to win and cover. If there is one thing we learned from Week 15, it’s that big spreads are often not big enough. There are simply some awful football teams this year; one such team is the Browns. They are 3-11 and have lost 3 games in a row, including by 18 points to San Francisco and by a 31-3 margin at Chicago this past Sunday. Cleveland even lost to lowly Tennessee during this stretch. Rookie QB Shedeur Sanders has been better than Dillon Gabriel — but that’s not saying much. Head coach Kevin Stefanski’s squad is 3rd-to-last in total offense, and only Las Vegas is averaging fewer points per game than Cleveland.
 
There are also a lot of really good teams this year, including the Bills. They may not be where they want since the Patriots still lead the AFC East, but Josh Allen and company are 10-4 and coming off a huge road win at New England to keep their division-title hopes alive. At the very least, the Bills are well on their way to another playoff berth. These are simply 2 squads going in very different directions. As such, this is one of those double-digit spreads that still isn’t big enough. The Browns are 0-3 ATS in their last 3 overall and 2-5 ATS in the last 7 head-to-head meetings.

Bills vs Browns predictions: Buffalo Bills -10 (-125) available at time of publishing. Playable to -12.5.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get $250 in FanCash INSTANTLY when they make their first $50 wager! Join Fanatics Sportsbook, where you can bet on our Bills vs Browns predictions.

8:20 PM ET
Sun Dec 21
New England Patriots
Baltimore Ravens
Patriots
Ravens
Point Spread PickBest Bet
NE Patriots +3.0(-115)

For the first time all season, the Baltimore Ravens finally had an easy win in week 15. Of course, Cincinnati seemed deflated from the very start of last week’s game, and a Joe Burrow lead offense was out of its rhythm, failing to score a single point. The ravens deserve credit all around, they showed up and got the job done and they must-win situation, but it still doesn’t improve that their struggles have ceased. We also can’t dismiss that Baltimore still ranks a lowly 20th in total offensive EPA metrics, and they’re not much better on defense either (16th). Their secondary is even more concerning, ranked 19th in defensive EPA per pass and permitting 233.3 passing yards per game (26th). Even worse, only the 49ers sack the quarterback less (Baltimore ranks 31st, taking down the quarterback on only 4.14% of plays). We hate that for their matchup on Sunday night.

There is no reasonable evidence that suggests the Ravens are a better team than the Patriots entering Week 16. Baltimore’s edge is that they’re at home and that they have more experience in big-time matchups like this, a cyclical playoff participant under the era of John Harbaugh and Lamar Jackson. But when it comes to this season, the Patriots are the better team in every category. Offensively they rank 6th in total offensive EPA and 12th in total defensive EPA, not to mention they’re coming off a 10-game winning streak, which was broken in Week 15.

Speaking of Week 15, we’re not concerned about the Patriots because of one flawed half. Many teams fall victim to the magic of Josh Allen, who engineered yet another second half comeback last Sunday. New England showed its youth and inexperience last weekend, but otherwise they’ve been one of the most consistent programs in the NFL. In fact, only the Seahawks and Rams, two other 11-3 outfits, have a better point-differential than Mike Vrabel’s team (+7.6). 

Especially since they’re coming off a loss, there’s simply no way we could bet on the Ravens here. Too many times we’ve seen their defense capitulate, and even in an easy win last week, their offense was rather pedestrian (317 total yards, 15 first downs). Meanwhile, the Patriots have been a well-oiled machine and one of the best ATS teams all season (8-5-1, 61.5%). If we’re getting a field goal with the visitors, we’re taking it.

Patriots vs Ravens: Patriots +3 (-110) available at time of publishing. Playable at that number.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get $250 in FanCash INSTANTLY when they make their first $50 wager! Join Fanatics Sportsbook, where you can bet on our Patriots vs Ravens predictions.

NFL Best Bets
47.5%
Win %
28Wins
31Losses
1Pushes
Percentage only includes Wins and Losses

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, so we bring you free NFL best bets this week and across the whole season and post-season.

Best NFL Bets Today

The NFL action comes thick and fast during the season and we cover all of it. Our NFL Best Bets should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free. 

Best NFL Bets This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different.

You can often find great value early in the week and our experts will take an early look ahead, so we get our best bets for NFL this week posted on-site as soon as possible, so you can lock in those best lines and odds before the inevitable movement later in the week. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details those 3 star rated bets, making them our expert’s NFL Best Bets on this week’s games.

How We Decide Our Best NFL Bets at Pickswise

Each week of the NFL season, as our experts deep-dive into the stats and make their picks and predictions for the week’s coming games each expert handicapper gives their reasoning and the data to back up their selections. Through a robust process of debate and consideration, taking into account the odds, potential winnings and an expert judgement on the bet’s outcome, they come to a consensus on the confidence rating for each play. Only those that get a 3 star confidence rating through this process qualify as an NFL best bet.

All our handicappers vie for their picks to get the NFL best bet stamp, each and every week of the season. It’s this friendly competition amongst experts that ensures are NFL best bets are indeed the best NFL bets you’ll find anywhere.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over the season.

For more on our recommended NFL sportsbooks, check out our rankings for the best NFL betting sites. The best odds, a diverse range of NFL betting markets and an overall user-friendly app experience are just some of the key factors we consider.

Unsure where is best to place your online sports wagers? Or looking to make the most of new player bonuses and promo codes? Be sure to check out our
Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state. 


57 Wins from 2024/25 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2024 season, our team of expert NFL handicappers finished with 57 wins on our NFL best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week. 

Andrew Wilsher, Pickswise Managing Editor

NFL Playoff Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Best Bets FAQs

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets returned 57 wins across the 2024/25 season.

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.