NFL Best Bets

Get our experts’ best NFL bets this week and every week of the 2025/26 season. Our experts analyze their NFL picks and predictions across a whole host of markets to give you their best NFL Bets today.

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1:00 PM ET
Sun Nov 16
Cincinnati Bengals
Pittsburgh Steelers
Bengals
Steelers
Point Spread PickBest Bet
CIN Bengals +5.5(-108)

The Cincinnati Bengals and Pittsburgh Steelers will collide for the second time this season when these 2 AFC North rivals meet again on Sunday afternoon, this time in Pittsburgh. This is a fantastic spot for Cincinnati. It is coming off a bye, whereas the Pittsburgh just got beat up by the Chargers on Sunday Night Football this past weekend. The Bengals have not lost by more than 5 points since Week 6; I expect that streak to continue. As such, my Bengals vs Steelers pick is for the visitors to cover.

Head coach Zac Taylor’s team just defeated the Steelers 33-31 in the first head-to-head matchup of 2025 on October 16. Joe Flacco lit up the scoreboard in that contest and he remains on an absolute roll, with an 11-to-2 touchdown-to-interception ratio in 4 games since being traded from the Browns. Aaron Rodgers, on the other hand, has been picked off 4 times in the last 4 games — including twice during the Steelers recent 25-10 setback against the Chargers. With some obvious occasional exceptions, rivalry matchups in the AFC North are often hard-nosed and competitive regardless of any discrepancies in talent. I will rarely give more than 3 points in such a situation, and there is no way I’m giving 5.5 in this particular instance.

Cincinnati Bengals vs Pittsburgh Steelers prediction: Bengals +5.5 (-108) available at time of publishing. Playable to +3.5.

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4:25 PM ET
Sun Nov 16
Kansas City Chiefs
Denver Broncos
Chiefs
Broncos
Point Spread PickBest Bet
KC Chiefs -4.0(-105)

Heading into mid-November, not many people thought the defending AFC champion Kansas City Chiefs would be sitting in third place of the AFC West at 5-4. The Chiefs travel to Denver as a road favorite against the division-leading Broncos. Kansas City has won five of its last seven games since an 0-2 start, but looks to bounce back after dropping an AFC Championship rematch at Buffalo, 28-21 prior to the bye week. The Chiefs have failed to cover in their last two opportunities as a road favorite, with their last victory in this role coming in Week 3 against the Giants.

The Broncos started the season at 1-2, but have pulled off seven straight victories. Five of the past six wins for Sean Payton’s team have come by four points or fewer, capped off by a 10-7 home triumph over the Raiders last Thursday. Four times in this stretch, Denver has trailed in the fourth quarter, including the ridiculous 33-32 comeback win over the Giants when the Broncos were down 19-0.

Denver has posted a 2-0-1 mark against the spread as an underdog this season, while getting listed as a home ‘dog for the first time since Week 6 of 2024 against the Chargers. In both opportunities last season, the Broncos lost to L.A. and Pittsburgh when receiving points at home. Since 2020, the Chiefs have been listed as a touchdown favorite or higher in nine of the past 10 matchups. In last season’s finale, the Broncos blanked the Chiefs, 38-0 as 11.5-point home favorites as most of Kansas City’s starters sat out.

Although the Broncos are 6-1 against the spread in the last seven meetings with the Chiefs, many of those covers came as a heavy underdog. This pointspread is telling us that Kansas City is the right side here as a road favorite to bounce back from the loss at Buffalo.

Chiefs vs Broncos best bet: Chiefs -4 (-105) available at time of publishing. Playable to 5.

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8:15 PM ET
Mon Nov 17
Dallas Cowboys
Las Vegas Raiders
Cowboys
Raiders
Point Spread PickBest Bet
DAL Cowboys -3.5(-110)

Last Thursday night the Raiders were part of one of the worst NFL games in history, and that’s not a subjective comment. The Broncos and Raiders each earned just 10 first downs. Combined they only gained 408 total yards, averaging just 3.2 (LV) and 3.9 (DEN) yards per play. It was a mess of a game, and frankly there’s not much we can glean from it. Sure, Vegas’ defense played well and held the Broncos to just 10 points and forced two interceptions, but Denver is also known to play down to their competition. Just ask the Jets, Giants, and Texans.

In totality, the Raiders’ defense qualifies as very average. They allow 24.4 points per game (20th) and 320.8 yards per game (15th), which we think will be a huge problem in their Week 11 matchup. It’s especially a problem considering how mediocre the Raiders’ offense is, a group that ranks 26th in EPA per pass and 32nd in EPA per rush.

The Cowboys are the more flawed defense in this matchup (30th in EPA per pass and EPA per rush), but they are a far better offense. Dallas’ last outing was their worst from an offensive standpoint, generating just 333 yards (far from poor but still well below their standards) and 17 points in a loss against the Cardinals. Even with that loss and regression, they remain one of the most prolific offenses in the NFL (378.4 yards per game, 4th). 

Coming off a bye week, the Cowboys’ roster had to endure more than the memory of defeat. Beloved second year defensive end Marshawn Kneeland passed away due to mental health issues just a few days after their Week 9 loss, heavy and unexpected news that Cowboy players and coaches had to contemplate throughout their break. And while it may seem distasteful to weigh the effect of a player’s death as part of a handicap, it is something that objectively occurred and we must consider. In this case, we feel strongly that the Cowboys, who are led by a quarterback whose brother passed away under the same circumstances, come out on absolute fire for their fallen comrade. 

Dallas is a team built by offense, although they made a splash by trading for Bengals linebacker Logan Wilson and star interior lineman Quinnen Williams before the trade deadline. Combined with their poor performance in Week 9, we project to see the best version of the Cowboys and the Raiders struggling to keep up.

Cowboys vs Raiders best bet: Cowboys -3.5 (-110) available at time of publishing. Playable to 4.5.

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NFL Best Bets
45.0%
Win %
18Wins
22Losses
0Pushes
Percentage only includes Wins and Losses

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, so we bring you free NFL best bets this week and across the whole season and post-season.

Best NFL Bets Today

The NFL action comes thick and fast during the season and we cover all of it. Our NFL Best Bets should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free. 

Best NFL Bets This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different.

You can often find great value early in the week and our experts will take an early look ahead, so we get our best bets for NFL this week posted on-site as soon as possible, so you can lock in those best lines and odds before the inevitable movement later in the week. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details those 3 star rated bets, making them our expert’s NFL Best Bets on this week’s games.

How We Decide Our Best NFL Bets at Pickswise

Each week of the NFL season, as our experts deep-dive into the stats and make their picks and predictions for the week’s coming games each expert handicapper gives their reasoning and the data to back up their selections. Through a robust process of debate and consideration, taking into account the odds, potential winnings and an expert judgement on the bet’s outcome, they come to a consensus on the confidence rating for each play. Only those that get a 3 star confidence rating through this process qualify as an NFL best bet.

All our handicappers vie for their picks to get the NFL best bet stamp, each and every week of the season. It’s this friendly competition amongst experts that ensures are NFL best bets are indeed the best NFL bets you’ll find anywhere.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over the season.

For more on our recommended NFL sportsbooks, check out our rankings for the best NFL betting sites. The best odds, a diverse range of NFL betting markets and an overall user-friendly app experience are just some of the key factors we consider.

Unsure where is best to place your online sports wagers? Or looking to make the most of new player bonuses and promo codes? Be sure to check out our
Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state. 


57 Wins from 2024/25 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2024 season, our team of expert NFL handicappers finished with 57 wins on our NFL best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week. 

Andrew Wilsher, Pickswise Managing Editor

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NFL Best Bets FAQs

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets returned 57 wins across the 2024/25 season.

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.