NFL Parlays

NFL parlay picks today. Our expert NFL parlays have made +24.1 units profit this season, including the playoffs. Get the best odds for NFL parlays and same game parlays you can trust, every week of the 2025-26 NFL season.

Saturday's NFL Divisional Round parlay

4:30 PM ETSat Jan 17

4:30 PM ET

BUF Bills @ DEN Broncos · Point Spread

DEN Broncos +1.0

Reasoning

Our Analysis

Many pontificators in the betting world thought the Jaguars would successfully move on to the Divisional Round, anchored by Liam Coen and their new-look defense. That never came to be. Instead, Buffalo secured their first road playoff win since 1992, led by more heroic efforts from Josh Allen. The esteemed Bills quarterback seemed to injure his knee and throwing hand on the same drive early in the game, but that didn’t stop him from accruing 306 total yards and 3 total touchdowns. When it mattered, Trevor Lawrence threw 2 key interceptions, one on the final drive, to seal the Buffalo victory.

As usual, the Allen-led offense was more than effective, answering the call whenever needed. On the other hand, the Bills’ defense played good, not great, only a few times making stops when it mattered. Not ideal was that Jacksonville went 5-9 on 3rd downs and 3-4 in the red zone. In truth, if it wasn’t for Lawrence’s 2 interceptions, the final result might’ve been different. As usual, the onus of Buffalo’s future will remain with Allen and his ability, since we suspect their defense will continue to allow plenty of production from opponents. The Bills will face a much greater challenge this coming Saturday, up in elevation in Denver against a Broncos squad that knows how to win and will be coming off extended rest.

Denver is statistically the opposite of Buffalo. They can rely on their defense, a group that’s top-5 in nearly every metric (including a 1st-place ranking in opponent yards per game, 278.2), but their offense seems to only come alive when they need it. Bo Nix and his colleagues mostly present average to below average marks, particularly in yards per pass, where they generate just 6.4 (29th). This is true even though they own one of the best offensive lines in the NFL, permitting a sack on just 3.62% of plays (2nd overall). The good news for Denver is that they are good under pressure, averaging 7.7 points in the 4th quarter and successfully completing 5 4th-quarter comebacks this season. Of course, Josh Allen and the Bills are also pretty good in this category, too, averaging 9.2 4th-quarter points and earning a few 4th-quarter comebacks themselves.

We’re pretty certain this game will come down to the final drive. Since one of the NFL’s best quarterbacks will be facing one of the NFL’s best defenses, that makes this matchup all the more difficult to predict. At face value, the more rested team at home is generally the side to go with, especially considering their prowess on defense. Personally, we’d love to see Buffalo win, but the intangibles favor Denver.

Bills vs Broncos prediction: Broncos +1 (-110) available at time of publishing. Playable at that number.

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8:00 PM ET

SF 49ers @ SEA Seahawks · Point Spread

SEA Seahawks -7.5

Reasoning

Our Analysis

If you watched last week‘s game between the 49ers and the Eagles, it wasn’t completely surprising to see the result. Since Brock Purdy has returned as the 49ers’ starting quarterback, they’re offense has been humming, right up there with the best passing operations in the NFL. Despite throwing two interceptions, Purdy was ice cold when it mattered most, going 6-11 on third downs and engineering 13 fourth-quarter points against one of the NFL’s best defenses. Perhaps most impressive about San Francisco’s production was that they only possessed the ball for 24 minutes.

The Niners defense played well, but some of that is more on Philadelphia’s lackluster offense. The Eagles’ offensive operation has been pedestrian for most of the season, so it wasn’t surprising to see them stumbling through the second half, earning just 6 points and 104 yards in the final two quarters. Credit should be given to Robert Saleh and his roster, but we’re also not sure if it’s sustainable. That’s particularly true this weekend.

The Seahawks enter the divisional round off extended rest and they will host their first playoff game Saturday night. The dominance of their defense has been well documented, completely obliterating San Francisco in their last matchup in Week 18 (they held Brock Purdy and company to just 3 points and 173 yards). Offensively they left plenty on the field, garnering just 13 points themselves. Most impressively, they ran for 180 yards on 4.6 yards per carry, and completely controlled time of possession because of it (37:48 to 22:12). Their passing attack wasn’t that explosive, but Sam Darnold was efficient (20-26, 198 yards) and the game never felt within reach for the visiting Niners.

While the rematch might not look the exact same, we are expecting a similar result. San Francisco’s impressive victory last Sunday came at the cost of George Kittle, their all-pro tight end who’s as crucial in blocking as he is in the pass catcher. He tore his achilles and will be out for the remainder of the season, yet another big loss to a roster that’s been severely beaten up this year. Add to the fact that San Francisco will only have six days to prepare for battle after a very physical matchup in the wildcard round and it’s hard not to imagine a Seattle blowout.

49ers vs Seahawks prediction: Seahawks -7.5 (-105) available at time of publishing. Playable to 8.

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4:30 PM ET

Bills vs Broncos Same Game Parlay

SGP

Money Line

BUF Bills Win

Game Totals

Under 46.5

Anytime Touchdown Scorer

J. Allen (BUF) to score a TD

Reasoning

Bills vs Broncos SGP pick: Buffalo Bills ML over Denver Broncos (-108)

I don’t have a whole lot of faith in either team, but I have even less faith in Denver – especially in a playoff situation. There is no way to sugarcoat it; I think the Broncos are frauds. That’s not to say they aren’t a good football team; they just aren’t #1 seed caliber. Their 14-3 record features a whopping 11 one-possession wins. That includes by 2 points over the Jets at a neutral site, by 1 over the Giants at home, by 3 over Las Vegas at home, by 3 over Kansas City at home, by 1 in overtime against Washington, by 7 at Las Vegas and by 7 at Kansas City without Patrick Mahomes. You never have to apologize for winning in the NFL, but those are some rather alarming results.

Although this is not the best Bills team we have seen in recent seasons, this is a group that knows how to get the job done on the big stage. We just saw it again when Allen and company went into Jacksonville and took down a red-hot Jaguars squad. Denver may be the more well-rounded of the 2, but I’ll take Allen over Bo Nix in a head-to-head playoff showdown any day of the week.

Bills vs Broncos SGP pick: Under 46.5 (-110)

The under correlates nicely with Buffalo on the money line, because I don’t think the visitors can score enough on Denver’s defense to win some kind of high-octane shootout. The Broncos’ defense is simply too good for those types of shenanigans. Just as Allen has to play well to give the Bills a chance, so too does their defense. They are facing a Denver offense that has never been great but has become even worse since running back JK Dobbins was lost for the season in Week 10. Since Dobbins went down, the Broncos’ EPA per rush metrics plunged from 14th to 25th in the NFL

Asking Nix, a 2nd-year quarterback, to bear the burden in a playoff game against such an experienced opponent does not seem like an ideal scenario. On the other side of the ball, Allen has not had a ton of weapons to work with throughout this 2025 campaign, and now Gabe Davis is gone with a torn ACL – which he sustained last weekend against the Jaguars. I’m going with a relatively low-scoring affair on Saturday.

Bills vs Broncos parlay pick: Josh Allen to score a touchdown (-120)

Allen generally takes matters into his own hands when the stakes are highest. That should especially be the case now that Davis is sidelined and the receiver corps is even worse than it already was prior to last weekend. Allen rushed for 2 touchdowns in Buffalo’s victory at Jacksonville, giving him 9 in 14 lifetime postseason appearances. In his last 6 playoff games dating back to the 2023 campaign, the Wyoming product has found the end zone 7 times. It’s also worth noting that Allen scored 14 touchdowns in 16 regular-season outings (not including Week 18 against the Jets in which he took just 1 snap to extend his consecutive games played streak). Even against a vaunted Denver defense, there is no reason why Allen can’t score.

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What Is An NFL Parlay?

An NFL parlay is a type of bet where you combine multiple selections into a single wager. For an NFL parlay to win, all of the selections or bets need to win. While the difficulty of winning an NFL parlay increases with each selection you add, the odds can also greatly increase. To calculate the odds of a parlay you multiply the odds of the individual selections so the more selections, the bigger the parlay odds. You can also make use of our Parlay Calculator to take care of all of the math for you. For more on Parlays be sure to check out our Parlay betting guide.

Our experts will highlight the best NFL Predictions to combine into an NFL Parlay, offering you even more variation into how you want to wager on this week’s NFL action.

NFL Parlay Picks

Here at Pickswise, we have free NFL parlay picks every week of the NFL season. Our free NFL parlays include both traditional multi-game parlays which include our best parlay picks from the most popular markets including money line, spreads, and totals, as well as our NFL Same Game parlays. Each of our free NFL parlays will come with a full analysis for each leg, as well as the best odds available from all of the top online sportsbooks. Check back every week including for those primetime parlay picks on Mondays, Thursdays, and Sunday Night Football.

NFL Parlay Strategies & Tips

Parlay Bets despite their popularity can be one of the most difficult, but potentially most lucrative bets, with increased difficulty with each selection you add. It’s important to remember that over the course of the NFL season even experts will very likely lose more parlays than they win. However, the nature of parlay betting means the wins you do get turns more profit.

Here are some quick tips to better your chances of winning long-term with your NFL Parlays

Stick to 2, 3, or 4 team parlays – Any more than this will often not be profitable long term despite the increased parlay odds. Multiple sportsbooks and NFL betting experts report the win rate of 2-leg NFL parlays to be 49-52%, while 3-legs hit at about 27-30%, 4-legs at 15% and 5+ legs are successful less than 10% of the time.
Shop around for odds – Not all online sportsbooks offer the same odds, and while there is often only a marginal difference if you can wager three picks at -105 each instead of -120, your payout would be $744.21 instead of $616.20 to a $100 stake.
Avoid same-side NFL Parlays – Although popular amongst NFL bettors, parlaying heavy favorites or multiple overs bets for example, are loved by sportsbooks as they generally offer very poor value to the bettor.
Manage your bankroll – Being disciplined with your bankroll is key long term as not all parlays will win, particularly in the NFL, but if you keep your stake consistent, at odds of around 6/1, you only need to win 1 in 7 parlays to break even, any better than that is profit.

NFL Picks and Parlays

At Pickswise our experts do hours of research and statistical analysis ahead of every NFL game week, providing professional insight into the array of NFL betting markets available and where you can find the value. Our NFL parlays come with a full reasoning for each leg so you can feel confident using our ready-made parlays yourself.

If you prefer to put your own parlays together but want some inspiration or expert opinion on the selections to make, our range of NFL Picks and NFL Prop Bets are the perfect companions to our NFL parlay picks and exactly what you’re looking for. Not only that, our NFL Best Bets are an excellent starting point for your parlays, or the perfect way to round out that NFL Parlay needing one more selection.

How to bet on NFL Parlays

Betting on NFL picks and parlays is a quick and simple process with any online sportsbook. To create a parlay, you simply have to add multiple selections to your bet slip and click the parlay option before placing your wager.

Due to the popularity of NFL betting and also NFL parlays, sportsbooks pay a considerable amount of attention to these markets, and in shopping around you can find great variations in odds, spread lines, and often price boosts or bonuses such as Parlay insurance whereby you get your stake as a bonus bet if only one leg lets you down. Shopping around for these advantages is key to having long-term success with NFL parlays.

Unsure where is best to place your NFL parlay bets? Head over to our online sportsbook promotions page where we break down all the information and latest promo codes you’ll need to know to unlock bonuses and make your NFL betting easier.

What is an NFL Teaser Bet?

One of the ways to avoid the frustration of losing an against-the-spread bet by a point or two is with NFL teaser picks. For example, in a 2-team teaser, you get 6 points placed in your direction (-7 spread becomes -1) for both games. The caveat is that both teams must cover for your ticket to be graded a winner and the odds are similar to a single-game bet. Conversely in a parlay, you still wager on two teams but with the original spread and with better payout odds (usually 3:1). Teasers can be parlayed with 2,3,4,5 teams or more. NFL Teasers are a significant way to boost your parlays win probability as around 25% of NFL games end with a margin of exactly 3 or 7 points, so crossing those margins offers great value.

What Is A Same Game Parlay

A Same Game Parlay is just like a regular parlay wager, except all selections come from prop bets within one specific game. The obvious positive of a Same Game Parlay is that by combining multiple selections you can go for an even bigger win with the odds increasing with each selection.

Bettors will often use Same Game Parlays to wager on correlated props, and if you get it right the payouts can be huge. Take, for example, a team facing a poor pass defense with an elite QB, in that spot, you might take the QB to hit over their passing yards total and you can also parlay that with their favorite wide receiver to score anytime and the team to win.

There are some restrictions or odds adjustments on correlated bets within a same-game parlay but it’s still a great way to improve the probability of your NFL parlays being successful in the long-term.

How To Bet On A Same Game Parlay

With the Same Game Parlay’s increasing popularity, the majority of leading online sportsbooks now offer them across a number of sports, including the NFL. Some refer to them as One Game Parlays and Single Game Parlays, which are different in name, but the same in concept.

To bet on a same game parlay simply head to your preferred online Sportsbook, or where you can get the best odds for your picks. Unsure of the best online sportsbook for the NFL? Check out our guide to the best NFL betting sites today.

To bet a Same Game Parlay you must first click on the game you want to place a bet on, and then add each selection to your betslip. The Same Game Parlay odds update with each pick. Once you have added all of your selections, enter the amount you wish to wager and hit ‘place bet’. And that’s it, you’re on!

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NFL Parlays: Betting small to try to win big

Bet small, win big. That’s the aim of every NFL parlay and our team of experts spend hours each week crafting what they believe to be the perfect parlay to deliver a nice payout. Our handicappers are among the best in the business at doing just that, with each leg the product of intensive analysis from numerous members of the Pickswise capping team. Our record speaks for itself when it comes to NFL parlay expertise, throughout the 2023 season our NFL parlays had scored 38.5 units in profit.

Andrew Wilsher, Pickswise Managing Editor

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NFL Parlays FAQs

Can You Parlay NFL Win Totals?

You cannot parlay NFL Win Totals bets as the outcomes of the events are closely correlated. If you were to bet the Overs on the Saints, but the Unders on the Buccaneers for example, and the Saints beat the Bucs twice in a season, both outcomes are likely to increase their chances of winning.

What Is A Parlay Bet In NFL?

A parlay bet in the NFL is when you combine multiple straight bets into one single bet. Every pick within the parlay must win for the ticket to cash, but the odds also increase in line with the risk of adding more picks, making them fruitful if they hit.

Can You Parlay NFL Futures?

You can parlay certain NFL futures before and during the season, but it will vary from sportsbook to sportsbook. One example would be division winners, you can try to hit a big parlay and predict all 8 division winners in a season. Some sportsbooks will also allow you to parlay Player Awards such as Offensive and Defensive Rookie of The Year.

Are NFL Parlays Worth It?

Parlays can be worth it, but it’s also worth keeping in mind that the more picks you have in a parlay the harder it will be to win. However, with the odds of each individual pick multiplying to give you the parlay odds, it allows you to bet smaller units to try and win bigger returns than a straight wager.

What Are The Disadvantages Of A Parlay?

The disadvantage of a parlay is its difficulty to win. While the odds are often great, adding each pick will also increase the risk of the bet winning as every selection has to win for the ticket to cash, a single losing leg with 5 winning ones still returns $0.

Why Are Parlays So Popular?

Parlays are popular because they offer the opportunity of betting small and win big. For example, if you were to parlay 6 teams against the spread, you should expect odds of around +4500 meaning a $50 bet would return $2,300.