NFL Picks

NFL picks for every game of the 2025-26 season. Our NFL expert picks are informed by key betting trends, statistical analysis and years of NFL betting experience. +32 units of profit, from 104 winning picks so far this season is the proof.

Our NFL picks this week include against the spread picks for every game in week 7, highlighted by Bengals vs Steelers on Thursday night football, 49ers vs Falcons on SNF and Monday Night football, featuring both Lions vs Bucs & Seahawks vs Texans

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Experts
Confidence Rating
7:00 PM ET
Today
ABC, ESPN
Tampa Bay Buccaneers
Detroit Lions
Buccaneers
Lions
Point Spread Pick
DET Lions -5.5(-110)

The Tampa Bay Bucs are arguably the best team in the NFL through 5 weeks. Baker Mayfield and an extremely deep wide-receiver corps has been their x-factor, a passing game that ranks in the top 10 and is the major catalyst behind the Bucs averaging 27.5 points per game (sixth). Mayfield has been damn near perfect. He is fourth overall with 1,539 yards and tied for third with 12 passing touchdowns. Entering Week 7 he has only thrown 1 interception. Lead running back Bucky Irving is doubtful for Monday night’s game and their ground attack isn’t as prolific (20th in rush yards per game), but they make up for it in their run-defense, a group that permits just 3.7 yards per carry and 88.5 rush yards per game (5th). Cohesive and with veterans in the most needed positions, Tampa Bay is an early NFC contender for a Super Bowl run — and there’s nothing fluky about it.

But this profiles as a very tough spot. The spread on this game keeps moving in the home team’s direction and we agree with it. Detroit was humbled last week at Arrowhead, which may be the case for most teams for the rest of the season, but the Lions are a true juggernaut at home. Since the 2023 season, head coach Dan Campbell’s outfit has averaged a ridiculous 34 points per game in front of their fans. This season it has already dropped 52 and 34 at Ford Field.

The Bucs are a solid run defense, but they are not as adept against the pass. They rank 26th in opponent yards per pass (7.6) and allow 231.2 pass yards per game (21st). They have only provided solid resistance against teams that are struggling through the air (Philadelphia, Houston, NYJ). The Lions have some issues on defense, again dealing with injuries, but they are one of the most potent (31.2 points per game) and explosive (second in points per play) offenses in the NFL, and they are at their best at home. Combine that with the fact that Detroit is coming off a loss and Tampa Bay is entering this contest with maximum, perhaps inflated confidence, and this is a recipe we love for the home team.

Tampa Bay Buccaneers vs Detroit Lions prediction: Lions -5.5 (-110) available at time of publishing. Playable to -6.

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Chris R. Farley
Game Totals PickBest Bet
Over 52.5(-110)

The Lions are already in a vulnerable position on defense, without Terrion Arnold and damaged depth in their cornerback and safety rooms. It’s even more dire now that Brian Branch, who lost his cool and started a fight after their loss at Kansas City last week, is now suspended for one game. Baker Mayfield and the Tampa Bay offense doesn’t need any help getting off the ground, ranked in the top-10 in nearly every offensive category, including a sixth best 27.5 points per game. In a dome against banged up Lions defense, we have little doubt that the Bucs can bring plenty of points to Ford Field.

Of course, on the other side we feel the same way. The Lions and Bucs can both get to the quarterback, both ranked in the top-12 in that category, but that’s about the only factor that concerns us for each offense. Of course, Tampa’s run defense is very formidable, but at home the Lions have run for 286 yards in two games behind one of the best running back tandems in the NFL. Considering the fact that Detroit was held to just 17 points on the road last weekend, a long week of preparation sets up for a dominant performance from Jared Goff, Jahmyr Gibbs and company. We recognized that this total is sky high, but there’s simply no other way we can look.

Tampa Bay Buccaneers vs Detroit Lions prediction: Over 52.5 (-110) available at time of publishing. Playable to 53.5.

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Chris R. Farley
10:00 PM ET
Today
ESPN
Houston Texans
Seattle Seahawks
Texans
Seahawks
Point Spread Pick
SEA Seahawks -3.0(-115)

The Houston Texans entered their bye week with much needed positivity. Of course, battling the Titans at home, a team that might be the worst in the NFL, and then dominating the Ravens with half a roster were certainly two advantageous positions. At the same time, CJ Stroud and company took advantage and did what they should have done, posting wins by margin. Particularly against Baltimore, we saw a side of the Texans’ offense that was virtually nonexistent up until that point. Stroud threw four touchdowns and their offense gained 417 total yards and 27 first downs in Charm City, completely decimating what was left of the Ravens’ defense. Houston’s defense, which has never been the problem and ranks first in opponent points per game (12.2), will surely benefit from two weeks of rest as they are healthier than they’ve been in a long time. A travel spot up to the Pacific Northwest is never easy, but two weeks for Houston to work on new schemes under first year offensive coordinator, Nick Caley, should pay dividends against a very good Seattle defense. 

Speaking of Seattle, what they did in Jacksonville last week was very impressive. After battling Tampa in Week 5 and losing a very close game at home, Seattle responded by holding the upstart Jaguars to just 273 total yards and 17 first downs at home. They also kept Trevor Lawrence and his colleagues to just four yards per play.  Perhaps most impressive, Lawrence was sacked seven times in that contest. Prior to Week 6, he was one of the best-protected quarterbacks in the league. 

We can’t say anything negative about Sam Darnold, either. The Seahawks new quarterback is top three in most passing categories and leads a potent air attack that ranks first in yards per pass (9.5). Seattle’s run game still leaves much to be desired (28th in yards per carry). This makes for a very interesting battle, but since we’ve barely seen positive performances from the Texans, we must give the nod to the home team, even with the hook over a 3-point spread.

Houston Texans vs Seattle Seahawks prediction: Seahawks -3 (-115) available at time of publishing. Playable at that number.

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Chris R. Farley
Game Totals Pick
Under 41.0(-110)

Even with Houston’s explosion at Baltimore 2 weeks ago, it’s not surprising to see this total so low. Houston might own the best defense in the NFL, with top-5 marks in opponent points per game and per play and in opponent yards per game and per play. What they’ll need most is an A+ pass defense against the Seahawks, as Sam Darnold has been electric despite throwing the ball less than any other team in the NFL (50.29% of plays). Strength meets strength in this sense, since Houston holds opposing quarterbacks just 6.3 yards per pass (5th) and has picked off enemy throwers on 3.27% of dropbacks. We expect Seattle’s run game to be very ineffective against the Texans, who permit just 3.9 opponent yards per rush (9th).

The same story repeats on the other side of the ball, where we project CJ Stroud to be running for his life for the majority of this contest. Seattle’s pass rush is exceptional, sacking enemy quarterbacks on 8.1% of plays. And the ‘Hawks are even better than Houston against the run (3.3 opponent yards per carry). 

As if both defenses need any more support, Monday is forecasted to be a sloppy, rainy evening in Seattle in addition to 2 previous days of rainy weather. That means the field should be less than ideal for speed. Perhaps a few random turnovers could push this game over if it gives either offense multiple short fields, but we have a hard time projecting this to eclipse 40 points.

Houston Texans vs Seattle Seahawks prediction: Under 41 (-110) available at time of publishing. Playable to 40.5.

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Chris R. Farley
7:00 PM ET
Today
ABC, ESPN
Tampa Bay Buccaneers
Detroit Lions
Buccaneers
Lions
Point Spread Pick
DET Lions -5.5(-110)

The Tampa Bay Bucs are arguably the best team in the NFL through 5 weeks. Baker Mayfield and an extremely deep wide-receiver corps has been their x-factor, a passing game that ranks in the top 10 and is the major catalyst behind the Bucs averaging 27.5 points per game (sixth). Mayfield has been damn near perfect. He is fourth overall with 1,539 yards and tied for third with 12 passing touchdowns. Entering Week 7 he has only thrown 1 interception. Lead running back Bucky Irving is doubtful for Monday night’s game and their ground attack isn’t as prolific (20th in rush yards per game), but they make up for it in their run-defense, a group that permits just 3.7 yards per carry and 88.5 rush yards per game (5th). Cohesive and with veterans in the most needed positions, Tampa Bay is an early NFC contender for a Super Bowl run — and there’s nothing fluky about it.

But this profiles as a very tough spot. The spread on this game keeps moving in the home team’s direction and we agree with it. Detroit was humbled last week at Arrowhead, which may be the case for most teams for the rest of the season, but the Lions are a true juggernaut at home. Since the 2023 season, head coach Dan Campbell’s outfit has averaged a ridiculous 34 points per game in front of their fans. This season it has already dropped 52 and 34 at Ford Field.

The Bucs are a solid run defense, but they are not as adept against the pass. They rank 26th in opponent yards per pass (7.6) and allow 231.2 pass yards per game (21st). They have only provided solid resistance against teams that are struggling through the air (Philadelphia, Houston, NYJ). The Lions have some issues on defense, again dealing with injuries, but they are one of the most potent (31.2 points per game) and explosive (second in points per play) offenses in the NFL, and they are at their best at home. Combine that with the fact that Detroit is coming off a loss and Tampa Bay is entering this contest with maximum, perhaps inflated confidence, and this is a recipe we love for the home team.

Tampa Bay Buccaneers vs Detroit Lions prediction: Lions -5.5 (-110) available at time of publishing. Playable to -6.

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Chris R. Farley
Game Totals PickBest Bet
Over 52.5(-110)

The Lions are already in a vulnerable position on defense, without Terrion Arnold and damaged depth in their cornerback and safety rooms. It’s even more dire now that Brian Branch, who lost his cool and started a fight after their loss at Kansas City last week, is now suspended for one game. Baker Mayfield and the Tampa Bay offense doesn’t need any help getting off the ground, ranked in the top-10 in nearly every offensive category, including a sixth best 27.5 points per game. In a dome against banged up Lions defense, we have little doubt that the Bucs can bring plenty of points to Ford Field.

Of course, on the other side we feel the same way. The Lions and Bucs can both get to the quarterback, both ranked in the top-12 in that category, but that’s about the only factor that concerns us for each offense. Of course, Tampa’s run defense is very formidable, but at home the Lions have run for 286 yards in two games behind one of the best running back tandems in the NFL. Considering the fact that Detroit was held to just 17 points on the road last weekend, a long week of preparation sets up for a dominant performance from Jared Goff, Jahmyr Gibbs and company. We recognized that this total is sky high, but there’s simply no other way we can look.

Tampa Bay Buccaneers vs Detroit Lions prediction: Over 52.5 (-110) available at time of publishing. Playable to 53.5.

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $200 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Buccaneers vs Lions predictions.

Chris R. Farley
10:00 PM ET
Today
ESPN
Houston Texans
Seattle Seahawks
Texans
Seahawks
Point Spread Pick
SEA Seahawks -3.0(-115)

The Houston Texans entered their bye week with much needed positivity. Of course, battling the Titans at home, a team that might be the worst in the NFL, and then dominating the Ravens with half a roster were certainly two advantageous positions. At the same time, CJ Stroud and company took advantage and did what they should have done, posting wins by margin. Particularly against Baltimore, we saw a side of the Texans’ offense that was virtually nonexistent up until that point. Stroud threw four touchdowns and their offense gained 417 total yards and 27 first downs in Charm City, completely decimating what was left of the Ravens’ defense. Houston’s defense, which has never been the problem and ranks first in opponent points per game (12.2), will surely benefit from two weeks of rest as they are healthier than they’ve been in a long time. A travel spot up to the Pacific Northwest is never easy, but two weeks for Houston to work on new schemes under first year offensive coordinator, Nick Caley, should pay dividends against a very good Seattle defense. 

Speaking of Seattle, what they did in Jacksonville last week was very impressive. After battling Tampa in Week 5 and losing a very close game at home, Seattle responded by holding the upstart Jaguars to just 273 total yards and 17 first downs at home. They also kept Trevor Lawrence and his colleagues to just four yards per play.  Perhaps most impressive, Lawrence was sacked seven times in that contest. Prior to Week 6, he was one of the best-protected quarterbacks in the league. 

We can’t say anything negative about Sam Darnold, either. The Seahawks new quarterback is top three in most passing categories and leads a potent air attack that ranks first in yards per pass (9.5). Seattle’s run game still leaves much to be desired (28th in yards per carry). This makes for a very interesting battle, but since we’ve barely seen positive performances from the Texans, we must give the nod to the home team, even with the hook over a 3-point spread.

Houston Texans vs Seattle Seahawks prediction: Seahawks -3 (-115) available at time of publishing. Playable at that number.

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Chris R. Farley
Game Totals Pick
Under 41.0(-110)

Even with Houston’s explosion at Baltimore 2 weeks ago, it’s not surprising to see this total so low. Houston might own the best defense in the NFL, with top-5 marks in opponent points per game and per play and in opponent yards per game and per play. What they’ll need most is an A+ pass defense against the Seahawks, as Sam Darnold has been electric despite throwing the ball less than any other team in the NFL (50.29% of plays). Strength meets strength in this sense, since Houston holds opposing quarterbacks just 6.3 yards per pass (5th) and has picked off enemy throwers on 3.27% of dropbacks. We expect Seattle’s run game to be very ineffective against the Texans, who permit just 3.9 opponent yards per rush (9th).

The same story repeats on the other side of the ball, where we project CJ Stroud to be running for his life for the majority of this contest. Seattle’s pass rush is exceptional, sacking enemy quarterbacks on 8.1% of plays. And the ‘Hawks are even better than Houston against the run (3.3 opponent yards per carry). 

As if both defenses need any more support, Monday is forecasted to be a sloppy, rainy evening in Seattle in addition to 2 previous days of rainy weather. That means the field should be less than ideal for speed. Perhaps a few random turnovers could push this game over if it gives either offense multiple short fields, but we have a hard time projecting this to eclipse 40 points.

Houston Texans vs Seattle Seahawks prediction: Under 41 (-110) available at time of publishing. Playable to 40.5.

You can bet on our Texans vs Seahawks prediction with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!

Chris R. Farley

Why Trust our NFL Picks

Through the first five weeks of the 2025 season our record speaks for itself. Our team of handicappers have racked up 54 winning NFL against the spread and moneyline picks (and 1 push), for +30.3 units of profit. On top of that, our NFL over/under picks have landed on 3 games, for a profit of +2.5 units. When you combine the two, our expert NFL picks have scored +32.7 units of profit so far this season.

PickWinsLossesProfit (betting units)
Sides (ATS & Moneyline)5438+30.3
Over/Under5043+2.5
Total10481+32.7

At Pickswise, every NFL pick is backed by years of betting experience, advanced data analysis, and a proven track record of success. Our team of handicappers studies line movement, injury reports, historical trends, and matchup stats to deliver informed recommendations — not guesses. We publish our results openly, update our predictions as new information emerges, and never hide behind vague analysis. Whether you’re looking for expert spreads, totals, props, or parlays, our mission is simple: give you honest, well-researched picks that stand up over time.

Free NFL Picks Explained

We firmly believe expert NFL picks should be free, so you’ll find our NFL picks today, and every day of the season, right here. We publish our free NFL picks for every game, at least a few days in advance of gameday, so you know who the experts are backing without missing out on the early value in the betting markets.

There’s almost an infinite way to bet on the NFL, from NFL picks against the spread, moneyline, over/under, NFL Parlays, and NFL Prop Bets, there is a bet type for every kind of football fan, so we provide NFL picks for every bet type. Some bettors like to specialize in a single particular type of NFL pick, while others like to have a diverse range and bet on anything they feel is a value pick.

Here at Pickswise, we have something for everyone. Our team of handicappers have a wealth of experience in making NFL picks across all these betting markets, leaving no stone unturned ahead of every game and every pick of the 2025 NFL season. If you’re looking for more information on NFL bet types, You can find our expert breakdown of each below.

NFL Picks Against the Spread

The most popular way to bet on the NFL is against the spread (ATS). With these wagers, you are not picking a simple winner or loser of a game. Instead, ATS betting is placing your money that Team A wins by a certain amount of points or that Team B will keep the game closer than oddsmakers expect, in other words, not lose by that same amount of points.

For Example

Philadelphia Eagles -7 – Philadelphia must win by 8 or more points to cover the spread.
Chicago Bears +7 – Chicago must win, or lose by 6 or fewer points to cover the spread.
Tie Scenario – If the game ended 27-20 to Philadelphia, the spread would be a tie, or a push and stakes would be returned.

  • The team that covers the spread wins the game outright around 80% of the time.
  • Road teams going into games as the favorite have covered the spread at 64% so far this season
  • Teams coming off a blowout loss (20+ points) tend to rebound against the spread, 57% of the time.

Free NFL Over / Under Picks

Another exciting way to still get in on the NFL action is with totals wagers. In these bets you don’t take a side, but whether the two teams will combine to score over or under the total number of points that the oddsmakers have set. Already since sports betting has been legalized we’ve seen many occasions where a hail mary, missed FG or XP has cost over or unders bettors, so be prepared to be in for the long haul with your totals bets. We preview every game of the NFL season, providing insight into the game as a whole alongside expert NFL picks so you can make informed NFL totals bets.

  • Overall, unders have proven the value pick in recent seasons, as defenses have caught up with scoring trending down since 2021
  • Unders bets have the edge in divisional games, landing 57% of the time. This trend gets stronger late in the season (week 13 onwards), especially in cold weather conditions.
  • Unders bets have landed on 58% of primetime games, as public betting tends to have a bias for the overs in these games.

Money Line NFL Picks

Ask any seasoned NFL bettor and they’ll tell you that ATS betting is exciting, but can also be frustrating. It is important to keep in mind that NFL teams only need to win by one, of course, they’d love to win by more, but they’ll change their schemes late on to secure a win, not to ensure they cover the spread. Your research could have given you the right side, but if they win by 6 instead of 7 your -6.5 bet is a loss. Therefore a lot of bettors like to keep it simple and take our expert NFL Money Line picks and bet on the NFL straight up.

  • Through the first 4 weeks of the 2025 season 6+ point favourites have been strong straight up, with a 16-2-1 record
  • Short underdogs (+1 to +3 on the spread) win outright 43% of the time, offering better value on the moneyline than the spread
  • Underdogs in lower scoring road games (less than 42 total points) win outright 39% of the time, but often at better prices than this record suggests.

2025-26 NFL Schedule 

This will be the 106th season in league history and is set to kick off with the NFL Kick-Off game on Thursday, September 4, hosted by the defending Super Bowl Champions Philadelphia Eagles, who take on the Dallas Cowboys. The regular season will come to a conclusion on January 4, 2026 with the NFL Playoffs scheduled to begin the following weekend on the 10th, 11th & 12th of January 2026. Super Bowl LX is scheduled for February 8, 2026, at Levi’s Stadium in San Francisco, California, the home of the 49ers.

NFL Playoff Picks

You can find our NFL picks for the 2026 Playoffs, right here, for free. Wildcard Weekend is scheduled to start January 10, upon the conclusion of week 18 our experts start to make their picks and predictions for the first round of the playoffs and after each round is concluded we prepare for the coming weekend, all the way up to the Super Bowl.

NFL Playoff Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Expert Picks

Our NFL Football picks will be for every game throughout the regular season, with primetime games and the top matchups each week getting additional expert coverage which will extend to every playoff game. These NFL Football picks will come alongside analysis and the latest stats and trends to consider when betting. You can also find our NFL Best Bets for the top plays of the week and a confidence rating for our expert handicapper.

Looking for alternative football picks? then head to our College Football Picks page, where you’ll find the same level of expertise from the Pickswise handicapping team for all the headline games in the 2025 NCAA football season.

More Than Just NFL Football Picks

We also specialize in every major North American sport including the MLB, NBA, NHL, College Football, and College Basketball. Check out our site every day for some of the best bets in every major athletic contest and make sure to follow us on social media as well.

Andrew Wilsher, Managing Editor of Pickswise

Statistical Approach to NFL Picks

It’s our goal to provide you with the best NFL picks in the market. Our expert handicappers are all specially selected and assessed prior to joining the team to ensure their analysis. experience and results are among the best in the industry. Each capper will put hours of research into each pick and many have built statistical models to find their moneyline, spread and over/under picks so you don’t have to. Check out all of our cappers’ free NFL picks here every week of the season. 

Andrew Wilsher, Pickswise Managing Editor

NFL Picks FAQs

To bet against the spread in the NFL you are either betting the favorite to win by x number of points or the underdog to win, or lose by fewer than x points. For example the Chiefs -7 points or the Panthers +7 points.

The number of points is set by sportsbooks and is often referred to as the line

 

Pickswise is the best website to get free NFL picks against the spread. Our handicappers provide free insight, analysis, and data to back up which way they’re siding against the spread for every NFL game. So far this NFL season our experts have secured 86 winning NFL picks for a profit of 26 units

Pickswise is the best place to get free expert NFL picks. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week.

Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods. Our profit this season is 26 units and rising, so don’t miss out on the best NFL picks this week.

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