Arizona Diamondbacks vs Milwaukee Brewers Prediction, Odds and Picks for Today, 04/28/26

After a day off, the Arizona Diamondbacks and Milwaukee Brewers return to action on Tuesday night to open a three-game series. Milwaukee will send Chad Patrick to the mound who is 1-1 with a 2.35 ERA through five starts. While Patrick has pitched effectively overall, he hasn’t earned a win since April 4 and has struggled to work deep into games, meaning Milwaukee may need to rely on its bullpen early. That could be important, as the Brewers bullpen owns a 4.09 ERA. 

Arizona will counter with Merrill Kelly, who is coming off a rough outing against the White Sox in which he allowed eight earned runs on 10 hits over 4.1 innings. On the season, Kelly is 1-1 with a 9.31 ERA through two starts. The Diamondbacks badly need a bounce-back effort from Kelly, because if he doesn’t, the Diamondbacks bullpen has had issues as well, entering with a 4.67 ERA. Offensively, the Diamondbacks are hitting the ball way better than the Brewers. In their last 11 games, Arizona has a .854 OPS and is averaging 6.2 runs per game in that span. For the Brewers, they have a .617 OPS in their last 12 games and are averaging 4.3 runs per game. While the Brewers hold a slight edge on the mound, the Diamondbacks have the more dangerous lineup. With questions surrounding Kelly, Patrick’s limited length, and both bullpens carrying shaky numbers, this sets up as a game where both offenses can contribute. Look for runs on both sides, making the over the best play in this matchup.  

Diamondbacks vs Brewers prediction: Over 8  (-110) available at time of publishing. Playable at that number.

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