Baltimore Orioles vs Cleveland Guardians Prediction, Odds and Picks for Today, 04/18/26

The Baltimore Orioles and the Cleveland Guardians have split the first 2 games of their 4-game weekend series, and Game 3 is set for Saturday afternoon. Dean Kremer is the scheduled starter for Baltimore in this game marking his 2nd start of the season. His first outing resulted in 9 strikeouts to 0 walks across 5 innings, but he did allow 3 home runs and 4 total runs to cross the plate. It was encouraging for Kremer backers and Orioles fans to see his increased whiff rate, but Kremer is not someone I fully trust without a larger sample of success.

Gavin Williams is set to start this game for Cleveland as he makes his 5th start of the season. Williams has had a pretty tough schedule so far, facing the Dodgers, Cardinals, Royals, and Mariners. Williams has allowed a home run in 3 of those 4 starts, and his 16 walks issued are a major concern. He has struck out 29 batters in that sample, and that strikeout production will need to remain high in order to avoid poor outings. While his command is an issue, Williams is still my preferred starter in this game, and I lean towards a Guardians win at home given current pricing.

Cleveland Guardians vs Baltimore Orioles prediction: Guardians ML (-132) available at time of publishing. Playable to -135.

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