Boston Red Sox vs Baltimore Orioles Prediction, Odds and Picks for Today, 04/26/26

The first of Sunday’s games is the Boston Red Sox vs the Baltimore Orioles. It has been quite a weekend for the Red Sox. They were whipped on Friday, 10-3, then responded on Saturday with an explosive 17-1 victory. The game was barely finished when it was announced that Alex Cora and most of the coaching staff had been fired. So of course, the main question Sunday is how the Red Sox will respond after all of that. With their odds well into plus money territory, I am willing to bet the Red Sox respond positively on Sunday, and I will take them to win.

On the mound are Connelly Early and Kyle Bradish. Both are pitching well thus far into the season. Early is a young and promising arm who needs to reign in the free passes, but he is otherwise a solid pitcher. Bradish is the best arm in the Baltimore rotation. This game has a low run total, and that is a probable outcome given the pitching matchup and the emotional roller coaster of the weekend, but I think this is a spot where the Boston bats can step up and respond. I also think the Baltimore lineup is way too thin in the back half right now. Give me Boston.

Red Sox vs Orioles Prediction: Red Sox ML (+115) available at the time of publishing. Playable to +100.