Boston Red Sox vs Toronto Blue Jays Prediction, Odds and Picks for Today, 04/28/26

The Boston Red Sox took Game 1 of this series on Monday by a score of 5-0. On Tuesday night we will see the much-anticipated return of Trey Yesavage to the Toronto Blue Jays pitching rotation. He was dominant down the stretch last season and through out the run to the World Series. The Blue Jays offense had an off night on Monday against a very good pitcher in Ranger Suarez who only allowed one hit and struck out 10 batters. Their offense had been trending in a good direction, and I expect it to pick back up on Tuesday night.

Neither starting pitcher has faced any batters in the opposing team’s lineup, so there is no matchup history to look at. Payton Tolle is coming off an impressive 11 strikeout game in his last outing. This is a big game for the Blue Jays as with a loss they will drop to last place in the American League East division. The stadium will be buzzing with the return of Yesavage and the energy will be high. Give me the Blue Jays to bounce back from Monday’s defeat.

Red Sox vs. Blue Jays prediction: Blue Jays ML (-120) available at time of publishing. Playable at that number.

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