Chicago Cubs vs Chicago White Sox Prediction, Odds and Picks for Today, 05/15/26

We’re heading to Chicago as the Chicago Cubs and Chicago White Sox open up a 3-game series on the South Side. The Cubs will look to reset offensively after dropping 4 of their last 5 games, while the White Sox come into this matchup red-hot with 5 straight wins. The Cubs will hand the ball to Edward Cabrera, who enters with a 3-1 record, 3.88 ERA, 1.32 WHIP and 43 strikeouts across 46.1 innings pitched this season, while the White Sox counter with Sean Burke — who has quietly put together a solid season with a 2-3 record, 3.68 ERA, 1.09 WHIP and 36 strikeouts in 44 innings pitched. 

Taking a look at both offenses, the Cubs are averaging 3.5 runs and batting .184 in their last 10 games, while the White Sox are at 4.8 runs per game and hitting .259 in that span. With the hotter offense, the White Sox will look to get to Cabrera early in this matchup. Cabrera has given up 3 runs or more in each of his last 6 starts — a concerning stat heading into this game. While Burke may have given up 6 runs against the Mariners in his last start, he’s been much more reliable on the mound this season. Many may remember a White Sox team that lost 102 games last year, but this group has taken a major step forward and currently sits 2nd in the AL Central. With momentum on their side, look for the White Sox to kick off this series with a win at home — making it 6 in a row. 

Cubs vs White Sox prediction: White Sox ML (+125) at the time of publishing. Playable up to +105.

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