Chicago Cubs vs St. Louis Cardinals Prediction, Odds and Picks for Today, 05/29/26

The Chicago Cubs have been the streakiest team in baseball this season, now riding a 2-game win streak following a 10-game losing skid. Shota Imanaga (4.04 ERA, 1.07 WHIP) gets the start for Chicago, looking to make it 3 straight wins facing a St. Louis Cardinals squad that’s now dropped 4 in a row. Imanaga is coming off his worst stretch of the year and arguably of his career, allowing 15 ER in his last 10.1 IP, though he still sits in the 68th percentile with a 3.40 xERA and in the 86th percentile in pitching run value. Today, he faces a Cardinals lineup with weaker splits against left-handed pitching.

Despite his recent form, I’d still give Imanaga the edge over STL starter Andre Pallante (3.76 ERA, 1.25 WHIP). Oddly enough, Pallante has been worse off starting at home, posting a 4.82 ERA when playing in Busch Stadium and a 2.67 mark when on the road. He’ll be facing a Chicago lineup that ranks top-6 in wRC+ and OBP against RHP, scoring 17 runs over the last 2 games. With all things considered, I’ll take Chicago to extend the win streak to 3.

Cubs vs Cardinals prediction: Chicago Cubs ML (-135) at time of publishing. Playable to -140.

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