Cincinnati Reds vs Pittsburgh Pirates Prediction, Odds and Picks for Today, 05/01/26

At first glance, this line raises eyebrows. The Pittsburgh Pirates sit at 16-16 while the Cincinnati Reds are 20-11 and sit atop the NL Central, yet Pittsburgh opened as the favorite. That’s not an accident, it’s a signal. And the reason is simple: Mitch Keller. Keller continues to be one of the most underrated arms in baseball. He enters this matchup 2-1 with a 3.18 ERA, backed by a 3.09 FIP and a 1.15 WHIP. That’s the profile of a steady, reliable starter who consistently keeps his team in games. For years, the issue wasn’t Keller, it was the lack of support around him. This version of Pittsburgh is different. The lineup is more competent, more balanced, and capable of backing strong pitching performances.

On the other side, Brady Singer presents a far less stable outlook. He’s carrying an ERA and FIP hovering near 5.00, with an xERA sitting at 5.32. That’s a pitcher allowing consistent contact and struggling to limit damage, especially dangerous against a team that can capitalize when given opportunities. This isn’t about records, logos, or perception. It’s about pitching reliability. Keller gives Pittsburgh a clear edge, and when that edge exists, run line value follows. At +165, this is more than a play, it’s the epitome of value. This is bet of the day material.

Reds vs Pirates prediction: Pittsburgh Pirates -1.5 (+165) (RL) available at time of publishing. Playable to the number.