Houston Astros vs Cleveland Guardians Prediction, Odds and Picks for Today, 04/21/26

The Houston Astros picked up a 9-2 road win in the series opener against the Cleveland Guardians, collecting 13 hits while snapping a 4-game skid — including a weekend sweep at home in an interleague series against the St. Louis Cardinals. The win in the series opener also snapped a 5-game losing streak against American League opponents, and the road victory was just the second of the season in 11 tries. Houston entered Monday’s game just 1-9 in 10 road games. The 9 runs were the most for the Astros since going for 11 and 10 runs in back-to-back games in Sacramento against the A’s on April 4-5.

The Guardians took 3 of 4 games from the Baltimore Orioles over the weekend, and the first-place Guardians were feeling good about themselves. The 9 runs allowed were the most since getting dusted 13-1 on Sunday Night Baseball in Atlanta on April 12. The Over has cashed in 3 of the past 4 games, with Cleveland pitching allowing 5.3 runs per game in the past 4 contests. Houston has cashed high in 4 consecutive games, and 6 of the past 8 outings. Let’s go high in this matchup between RHP Ryan Weiss and LHP Parker Messick. The under cashed in Weiss’ first start on Thursday, while the total has stayed low in 3 of Messick’s 4 outings to date.

Astros vs Guardians prediction: Under 8 (-105) available at time of publishing. Playable to -120.

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