Los Angeles Dodgers vs San Francisco Giants Prediction, Odds and Picks for Today, 04/21/26

The Los Angeles Dodgers hit the road for the start of a three-game set against the rival San Francisco Giants at Oracle Park on Tuesday. The Dodgers split a four-game set on the road against the Colorado Rockies, outscoring the Rox 28-17 as the Over and Under split 2-2. The Under is 4-2 in the past six road games for the Dodgers, while going 5-3 in the previous eight outings. The Under is 3-0 in the past three starts by Dodgers RHP Yoshinobu Yamamoto, and he has allowed two or fewer runs in each of his four outings, posting quality starts in each of the appearances.

For the Giants, they’re coming off a 3-0 loss in Washington, and they’ve scored three or fewer runs in six of the past eight outings, with the Under holding a slight 4-3 edge in the past seven games. At home, the Under is 2-1-1 in the past four games, too. The Over-Under has split in the first four starts by RHP Landon Roupp. The Under is 3-2 in the past four meetings between these rivals at Oracle Park. Let’s go low on the total, but don’t get carried away.

Under 7 (-105) at time of publishing. Playable to -110.