Minnesota Twins vs Cleveland Guardians Prediction, Odds and Picks for Today, 05/10/26

The Minnesota Twins and Cleveland Guardians wrap up a three-game series at Progressive Field on Sunday afternoon, and it’s a rubber game. The Guardians picked up the 6-4 win as slight favorites in the series opener behind LHP Parker Messick on Friday, while the Twins returned the favor with a low-scoring 2-1 win with RHP Joe Ryan on the bump Saturday at even-money. That snapped a three-game losing streak for the Twins. It was just the second victory in the past 10 road games for the Twins, too. They turn to RHP Andrew Morris to serve as the opener, his first start of the season. HE has managed a 4.96 ERA across 16 1/3 IP in seven relief appearances.

For the Guardians, RHP Gavin Williams (5-2, 3.28 ERA and 1.09 WHIP) takes the ball. He has a 2-0 record and a sparkling 0.89 ERA across 20 1/3 IP in three starts at home this season, and he has racked up 28 strikeouts with teams hitting just .129 against him at Progressive Field. Last season, he was 1-1 with a 3.21 ERA across 14 IP in three starts against the Twins. The Guardians are 6-1 in the past seven starts with Williams on the bump. Let’s back Cleveland to get the job done with their stopper on the mound.

Guardians ML (-146) at time of publishing. Playable to -170.