New York Yankees vs Houston Astros Prediction, Odds and Picks for Today, 04/25/26

The Houston Astros are one of baseball’s most intriguing storylines to follow at the moment considering the pitching staff has allowed nearly the most runs in the league, while the offense ranks top-5 in runs scored. Mike Burrows (6.75 ERA, 1.69 WHIP) takes the mound for Houston with some refreshing underlying numbers compared to his recent output. A 3.90 xERA compared to 6.75 ERA and .378 BABIP compared to .249 xBA suggests Burrows is due for some serious positive regression.

Ryan Weathers (3.18 ERA, 1.24 WHIP) gets the start for New York fresh off his best outing of the season, tossing 7.1 scoreless innings with 8 strikeouts against Kansas City. Neither bullpen has been reliable at this point in the season, and neither unit is well rested entering this contest. With that being said, I’ll lean on the starters in this spot and take the first five innings under, likely removing the bullpens from the equation.

New York vs Houston prediction: First 5 innings under 5 (-115) available at time of publishing. Playable at that number or better.